一氧化氮合酶抑制剂的研究进展

一氧化氮（ｎｉｔｒｉｃｏｘｉｄｅ，ＮＯ）是一种能调节细胞多种功能的信息分子，它参与心血管、外周和中枢神经以及免疫等系统生理过程和生物信号的调节。体内组织中的ＮＯ由ＮＯ合酶（Ｎｉｔｒｉｃｏｘｉｄｅｓｙｎｔｈａｓｅ，ＮＯＳ）催化左旋精氨酸而合成，合成后的ＮＯ迅速跨膜扩散释放。各种调节ＮＯ释放的因素均作用于ＮＯＳ催化的化学反应过程，而体内影响该反应的ＮＯＳ在各组织的表达不同。特异性ＮＯＳ抑制剂通过调控ＮＯ的合成，对ＮＯＳ表达相关的各种疾病的预防和治疗具有重要的临床意义。本文对近年来ＮＯＳ抑制剂的研究进展作一概述。

Progress in inhibitors of nitric oxide synthase

Nitric oxide (NO)is a signal molecule, which can regulate cellular function, physiological course and biological signal in the cardiovascular system, peripheral and central neural system, and immunologic system in vivo , NO is generated from L arginine by family enzymes known as nitric oxide synthase (NOS). Synthetic NO is rapidly released across transmembrane diffusion. All kinds of factors which modulate NO release affect the chemical reaction course of NOS; however, NOS in a variety of tissues have different expression. The specific inhibitors of NOS may be useful in the prevention/therapy of a variety diseases associated with induction of NOS. In this review, a brief summarization is made on inhibitors of NOS along with examples of their use in the studies of medicine.