Cromakalim does not act as a calcium antagonist in isolated human mesenteric artery cells. |
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| Authors: | S V Smirnov P I Aaronson S N Russell |
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| Affiliation: | Department of Pharmacology, United Medical School of Guy's Hospital, London, UK. |
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| Abstract: | ![]()
The effects of cromakalim and its active enantiomer BRL 38226 on voltage-gated Ca2+ channels in smooth muscle cells isolated from human mesenteric arteries were studied using the whole cell patch-clamp technique. Neither of these drugs affected the Ca2+ channel current in these cells. These results suggest that the efficacy of cromakalim in lowering blood pressure in human beings does not involve a Ca2+ channel antagonistic effect. |
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