Evaluation of commercial assay detecting specific immunoglobulin g in oral fluid for determining measles immunity in vaccinees |
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| Authors: | Kremer Jacques R Muller Claude P |
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| Affiliation: | Institute of Immunology, WHO Collaborative Centre for Measles, WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L-1011 Luxembourg. |
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| Abstract: | ![]()
A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (-7.4%; confidence interval: -1.5 to -13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low. |
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