Diabetic Macular Edema and Diode Subthreshold Micropulse Laser: A Randomized Double-Masked Noninferiority Clinical Trial |
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| Affiliation: | 1. The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University, Belfast, United Kingdom;2. The Northern Ireland Clinical Trials Unit (NICTU), Belfast, United Kingdom;3. The Division of Health Sciences, University of Warwick, Coventry, United Kingdom;4. The Centre for Public Health, Queens University, Belfast, United Kingdom;5. The Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom;6. The Regional Intensive Care Unit, Royal Victoria Hospital, Belfast, United Kingdom;7. Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom;8. The Manchester Academic Health Science Centre, Manchester Royal Eye Hospital and Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;9. Bristol Eye Hospital, Bristol, United Kingdom;10. Royal Free Hospital NHS Foundation Trust, London, United Kingdom;11. Hull and East Yorkshire Hospital, Hull and East Yorkshire NHS Trust, Hull, United Kingdom;12. Kings College Hospital NHS Foundation Trust, London, United Kingdom;13. John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom;14. Hillingdon Hospitals NHS Foundation Trust, London, United Kingdom;15. Bradford Teaching Hospitals NHS Trust, Bradford, United Kingdom;16. Stoke Mandeville Hospital, Buckinghamshire NHS Trust, Aylesbury, United Kingdom;17. NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom;18. Frimley Park Hospital NHS Foundation Trust, Camberley, United Kingdom;19. James Cook University Hospital, South Tees Hospitals NHS Foundation Trust, Middlesbrough, United Kingdom;20. Zagazig University, Zagazig, Egypt;21. Hinchingbrooke Hospital North West Anglia NHS Trust, Hinchingbrooke, United Kingdom;22. Sunderland Eye Infirmary, Sunderland and Bioscience Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom;23. Newcastle Eye Centre and Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom |
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| Keywords: | Anti-VEGF Diabetic macular edema DME Macular laser Micropulse BCVA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" best-corrected visual acuity CI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" confidence interval CRT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" central retinal thickness CSME" },{" #name" :" keyword" ," $" :{" id" :" kwttgrferd0225" }," $$" :[{" #name" :" text" ," _" :" clinically significant macular edema dB" },{" #name" :" keyword" ," $" :{" id" :" kwrd022115" }," $$" :[{" #name" :" text" ," _" :" decibels DIAMONDS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" Diabetic Macular Oedema and Diode Subthreshold Micropulse Laser DME" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" diabetic macular edema EQ-5D-5L" },{" #name" :" keyword" ," $" :{" id" :" kwrd02tttttrrr25" }," $$" :[{" #name" :" text" ," _" :" EuroQoL ETDRS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" Early Treatment Diabetic Retinopathy Study FFA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" fundus fluorescein angiography ITT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" intention-to-treat logMAR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" logarithm of the minimum angle of resolution NEI-VFQ-25" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" 25-item National Eye Institute Visual Function Questionnaire NICE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" National Institute for Health and Care Excellence PP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" per-protocol PPI" },{" #name" :" keyword" ," $" :{" id" :" kwrd022ggg5" }," $$" :[{" #name" :" text" ," _" :" Patient and Public Involvement QALY" },{" #name" :" keyword" ," $" :{" id" :" kwrd0225kkkk" }," $$" :[{" #name" :" text" ," _" :" quality-adjusted life-year RCT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" randomized clinical trial RPE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0175" }," $$" :[{" #name" :" text" ," _" :" retinal pigment epithelium RR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0185" }," $$" :[{" #name" :" text" ," _" :" risk ratio SD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0195" }," $$" :[{" #name" :" text" ," _" :" standard deviation SL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0205" }," $$" :[{" #name" :" text" ," _" :" standard laser SML" },{" #name" :" keyword" ," $" :{" id" :" kwrd0215" }," $$" :[{" #name" :" text" ," _" :" subthreshold micropulse laser VEGF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0225" }," $$" :[{" #name" :" text" ," _" :" vascular endothelial growth factor VisQoL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0225ccc" }," $$" :[{" #name" :" text" ," _" :" Vision and Quality of Life Index |
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