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The Effect of a Comprehensive Rehabilitation Program on Respiratory Function and Functional Capacity on Patients After 1 Month to Liver Transplantation
Affiliation:1. Departamento de Medicina Universidade Federal do Ceará Fortaleza, Ceará, Brazil;2. Centro de Transplante, Hospital Umiversitário Walter Cantídio Universidade Federal do Ceará Fortaleza, Ceará, Brazil;3. Departamento de Cirurgia Universidade Federal do Ceará Fortaleza, Ceará, Brazil;4. Hospital de Messejana Dr Carlos Alberto Studart Gomes;1. Department of Cardiology, University Heart Center, University Hospital Zürich, Switzerland;2. Kantonsspital Winterthur, Switzerland;3. Department of Cardiovascular Surgery, University Heart Center, University Hospital Zürich, Switzerland;4. Department of Internal Medicine, University Hospital Zürich, Switzerland;5. Division of Cardiology, Department of Internal Medicine, Triemli Hospital, Zürich, Switzerland;6. Division of Cardiovascular Surgery, Triemli Hospital, Zürich, Switzerland;7. Cardiology, Zürcher Höhenklinik Wald, Switzerland;1. Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA;2. Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium;3. Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA;4. Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA;5. Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
Abstract:BackgroundPhysical exercise is prescribed in populations with chronic diseases, but data are scarce in the liver transplantation (LT) setting.ObjectiveThe aim of this study was to evaluate changes in forced expiratory volume in the first second, forced vital capacity, maximal inspiratory pressure, maximal expiratory pressure, 6-minute walking test (6MWT), 6-minute step test (6MST), Duke Activity Status Index, VO2 (mL/kg/min), and health-related quality of life (in patients submitted to a rehabilitation program, comprising physical exercise training, breathing techniques, and educational sessions after LT.MethodsThis cohort study enrolled patients to an 8-week period of thrice weekly comprehensive supervised rehabilitation program after 1 month of LT. A nonrandomized control cohort of LT patients were selected to match the rehabilitation group based on specific demographic data and severity of disease.ResultsThe rehabilitation group, compared with the control group, showed a significant improvement in respiratory parameters (forced vital capacity [0.33L vs 0.13L,P < .01]); exercise capacity (6MWT and 6MST 71.1 vs 34.1 meters; and 30.5 vs 7.5 steps; respectively P < .01); Duke Activity Status Index scores and VO2 (21.3 vs 10.2 and 9 vs 4.3; respectively P < .01); respiratory muscle strength (maximal inspiratory pressure 21.1 vs 15.1 cmH2O and maximal expiratory pressure 21.2 vs 10.2 cmH2O; P < .01); and quality of life (SF-36 physical component summary 12.4 vs 2.9 P < .01).ConclusionThese data suggest that improvements in physical fitness, respiratory parameters, and quality of life are achieved with a comprehensive rehabilitation program initiated early after LT.
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