| 联合检测血清胱抑素C和同型半胱氨酸在2型糖尿病肾病早期诊断中的意义 |
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| 引用本文： | 李君莲,木合塔尔·麦合素提,綦迎成. 联合检测血清胱抑素C和同型半胱氨酸在2型糖尿病肾病早期诊断中的意义[J]. 重庆医学, 2012, 41(7): 654-655. DOI: 10.3969/j.issn.1671-8348.2012.07.010 |
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| 作者姓名： | 李君莲 木合塔尔·麦合素提 綦迎成 |
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| 作者单位： | 1.新疆维吾尔自治区胸科医院检验科,新疆乌鲁木齐,830049;2.新疆喀什地区第一人民医院,冠心病监护病房,新疆喀什,844000;3.新疆维吾尔自治区胸科医院,新疆乌鲁木齐,830049 |
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| 摘 要： | 目的 探讨联合检测血清胱抑素C(Cys C)和同型半胱氨酸(Hcy)在2型糖尿病肾病早期诊断中的意义.方法 将70例2型糖尿病患者按糖尿病肾病诊断标准分为糖尿病肾病组(n=50)与糖尿病无肾损伤组(n=20),选择50例健康人作为正常对照组.同时检测3组患者的肌酐、尿素氮、糖化血红蛋白(GHbA1c)、尿微量清蛋白排泄率(UAER)、Cys C和Hcy.结果 糖尿病肾病组患者肌酐、尿素氮、UAER及Cys C水平高于糖尿病无肾损伤组和正常对照组(P＜0.05);糖尿病肾病和糖尿病无肾损伤组分别与正常对照组的GHbA1c水平比较,差异有统计学意义(P＜0.05).结论 联合检测Cys C和Hcy
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| 关 键 词： | 糖尿病肾病 胱抑素 同型半胱氨酸 肾功能试验 诊断 |
Significance of combined detection of serum cystatin C and homocysteine in early diagnosis of type 2 diabetic nephropathy |
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| Li Junlian,Muhetaerro·Maihesuti,Qi Yingcheng. Significance of combined detection of serum cystatin C and homocysteine in early diagnosis of type 2 diabetic nephropathy[J]. Chongqing Medical Journal, 2012, 41(7): 654-655. DOI: 10.3969/j.issn.1671-8348.2012.07.010 |
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| Authors: | Li Junlian Muhetaerro·Maihesuti Qi Yingcheng |
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| Affiliation: | 1.Department of Clinical Laboratory,Chest Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830049, China;2.Coronary Care Unit,the First People′s Hospital of Kashi in Xinjiang,Kashi,Xingjiang 844000, China;3.Chest Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830049,China) |
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| Abstract: | Objective To explore the significance of combined detection of serum cystatin C(Cys C) and homocysteine(Hcy) in early diagnosis of type 2 diabetic nephropathy.Methods 70 patients with type 2 diabetes mellitus divided into diabetic nephropathy group(n=50) and diabetes without kidney injury group(n=20) according to the diagnostic criteria for diabetic nephropathy,and 50 healthy people served as normal control group.Serum reatinine,blood urea nitrogen,glycated hemoglobin(GHbA1c),urinary albumin excretion rate(UAER),Cys C and Hcy of patients in the three groups were detected simultaneously.Results Levels of serum creatinine,bloos urea nitrogen,UAER and Cys C of patients in diabetic nephropathy group were significantly higher than those in diabetes without kidney injury group and normal control group(P<0.05).Compared levels of GHbA1c of patients in diabetic nephropathy group and diabetes without kidney injury group with those in normal control group,respectively,differences showed statistically significance(P<0.05).Conclusion Combined detection of Cys C and Hcy can serve as an important indicator for early diagnosis of kidney injury in patients with type 2 diabetic nephropathy. |
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| Keywords: | diabetic nephropathies cystatin homocysteine kidney function tests diagnosis |
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