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| CD44V6在胃癌组织中的表达及其临床意义 | |
| 引用本文： | 叶辉,王伟,张兴林,邬时国. CD44V6在胃癌组织中的表达及其临床意义[J]. 安徽医药, 2005, 9(7): 532-533 |
| 作者姓名： | 叶辉 王伟 张兴林 邬时国 |
| 作者单位： | 浙江省余姚市人民医院外科,浙江,余姚,315400;浙江省余姚市人民医院外科,浙江,余姚,315400;浙江省余姚市人民医院外科,浙江,余姚,315400;浙江省余姚市人民医院外科,浙江,余姚,315400 |
| 摘 要： | 目的探讨CD44V6在胃癌组织中的表达及其临床意义.方法回顾性研究42例胃癌手术标本,应用S-P免疫组化染色技术检测CD44V6蛋白在胃癌组织中的表达.结果胃癌组织中CD44V6阳性表达率为69.05 %(29 /42),与肿瘤大小、病理分级无关(P>0.05)、与浸润深度和淋巴结转移有关(P<0.05).结论 CD44V6的表达与胃癌的发生、浸润、淋巴结转移有关,对胃癌组织进行CD44V6蛋白的检测,有助于预测胃癌进展程度和淋巴结转移的诊断. |
| 关 键 词： | 胃肿瘤 CD44V6 免疫组织化学 |
| 修稿时间： | 2005-03-22 |
The expression of CD44V6 in human gastric carcinoma |
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| YE Hui,WANG Wei,ZHANG Xing-lin,WU Shi-guo. The expression of CD44V6 in human gastric carcinoma[J]. Anhui Medical and Pharmaceutical Journal, 2005, 9(7): 532-533 | |
| Authors: | YE Hui WANG Wei ZHANG Xing-lin WU Shi-guo |
| Abstract: | AimTo observe the expression of CD44 splice variant V6(CD44V6) in human gastric carcinoma.MethodsParaffin embedded sections from 42 samples of gastric carcinomas were analyzed by immunohistochemistry for CD44V6 expression.Results Positive rate of CD44V6 expression was 69.05%(29/42).The expression of CD44V6 was closely related to tumor's invasion depth and lymphatic metastasis but not related to tumor's size and pathological grade.ConclusionsThe expression of CD44V6 correlates with the development,invasion and metastasis of gastric carcinoma. Determination of CD44V6 protein by immunohistochemistry might be useful in assessing tumor progression and lymphatic metastasis and in predicting prognosis of gastric cancer. |
| Keywords: | gastric carcinoma CD44V6 metastasis |
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