| Sca-1~+心肌干细胞的研究进展 |
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| 引用本文： | 康振峻,钟理,宋治远. Sca-1~+心肌干细胞的研究进展[J]. 心血管病学进展, 2009, 30(6) |
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| 作者姓名： | 康振峻 钟理 宋治远 |
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| 作者单位： | 第三军医大学附属西南医院心血管内科,重庆,400038 |
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| 摘 要： | 干细胞抗原1(Sca-1)是干细胞的一种重要表面标记物,体内许多干细胞都表达Sca-1。同样,心肌干细胞也表达Sca-1。目前研究发现,Sca-1+心肌干细胞能够分化为心肌细胞,对心肌梗死后心室重构与心肌再生具有明显作用,能够促进心脏的修复。因此,Sca-1+心肌干细胞有可能使心肌梗死的临床治疗取得实质性的进展。现综述了Sca-1+心肌干细胞的来源、分化、作用等方面。
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| 关 键 词： | 干细胞抗原1 心肌干细胞 分化 心肌细胞 |
Advances in Research in Sca-1~+ Cardiac Stem Cells |
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| KANG Zhen-jun,ZHONG Li,SONG Zhi-yuan. Advances in Research in Sca-1~+ Cardiac Stem Cells[J]. Advances in Cardiovascular Diseases, 2009, 30(6) |
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| Authors: | KANG Zhen-jun ZHONG Li SONG Zhi-yuan |
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| Affiliation: | KANG Zhen-jun; ZHONG Li; SONG Zhi-yuan(Department of Cardiology; Southwest Hospital; The Third Military Medical University; Chongqing 400038; China); |
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| Abstract: | Stem cell antigen-1 (Sca-1) is an important surface marker for stem cells;cardiac myocytes, and other somatic stem cells express Sca-1. Recently, a number of reports have suggested that Sca-1~+ cardiac stem cells were capable of differentiating into cardiac myocytes, which were significantly contributing to post myocardial infarction (post-MI) left ventricular remodeling and myocardium regeneration, and which could promote cardiac repair. Accordingly, Sca-1~+ cardiac stem cells might lead to clinically useful therapies for myocardial infarction. This paper reviews research done on the differentiation and role of Sca-1~+ cardiac stem cells. |
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| Keywords: | stem cell antigen-1 cardiac stem cells differentiation cardiac myocytes |
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