| 顶体蛋白酶抑制剂4-胍基苯甲酸盐对人精子功能的影响 |
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| 引用本文： | 赵亚南,纪亚忠,吕加国,易冰,盛毅,蒋丹. 顶体蛋白酶抑制剂4-胍基苯甲酸盐对人精子功能的影响[J]. 第二军医大学学报, 2000, 21(12): 1149-1151 |
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| 作者姓名： | 赵亚南 纪亚忠 吕加国 易冰 盛毅 蒋丹 |
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| 作者单位： | 第二军医大学长海医院全军生殖医学技术中心,上海,200433;第二军医大学药学院药物化学教研室 |
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| 基金项目： | 上海市科委重大课题基金! (92 43130 14 ) |
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| 摘 要： | 目的：研究顶体蛋白酶抑制剂４－胍基苯甲酸盐（ＫＦ－９５０）对人精子功能的影响。方法：体外用不同浓度的ＫＦ－９５０作用于人精子,观察其活动率;用免疫组化ＡＢＣ法观察ＫＦ－９５０对精子顶体结构的影响。结果：ＫＦ－９５０对人精子的作用与其浓度和明关。经≥０．２ｍｇ／ｍｌ ＫＦ－９５０处理,随着时间的延长以精子活动率明显下降,精子膜功能有不同程度的损害,顶体脱落率以及已发生顶体反应的精子死亡率明显上升。结
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| 关 键 词： | 顶体蛋白酶抑制剂 精子 顶体 |
Effects of acrosin inhibitor 4-guanidinobenzoate on human sperm function |
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| ZHAO Ya-Nan,JI Ya-Zhong,Lü Jia-Guo,YI Bing,SHENG Yi,JIANG Dan. Effects of acrosin inhibitor 4-guanidinobenzoate on human sperm function[J]. Former Academic Journal of Second Military Medical University, 2000, 21(12): 1149-1151 |
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| Authors: | ZHAO Ya-Nan JI Ya-Zhong Lü Jia-Guo YI Bing SHENG Yi JIANG Dan |
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| Abstract: | Objective: To study the effects of acrosin inhibitor 4 guanidinobenzoate (KF 950) on human sperm function. Methods: The viability, and membrane structure of human sperm were studied in vitro after treatment with a series concentration of KF 950. Results: With KF 950 more than 0.2 mg/ml and the time increasing,sperm mobility decreased, sperm membrane integrity was injured,and the shedding ratio of sperm acrosome and death ratio of sperm after acrosome reaction increased markedly. Conclusion: KF 950 may affect sperm function by damaging its membrane integrity. [ |
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| Keywords: | acrosin inhibitor sperm acrosom |
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