Iron deficiency in preschool children with autistic spectrum disorders |
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| Authors: | Ayhan Bilgiç Kağan Gürkan Serhat Türkoğlu Ömer Faruk Akça Birim Günay Kılıç Runa Uslu |
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| Affiliation: | 1. Malatya Government Hospital, Department of Child and Adolescent Psychiatry, Malatya Devlet Hastanesi, 44300 Malatya, Turkey;2. Ankara University School of Medicine, Department of Child and Adolescent Psychiatry, Ankara Üniversitesi Tip Fakültesi Cocuk ve Ergen Psikiyatrisi AD, 06100 Cebeci, Ankara, Turkey;3. Dr. Sami Ulus Children''s Health and Disease Education and Research Hospital, Department of Child and Adolescent Psychiatry, Dr. Sami Ulus Devlet Hastanesi, 06080 Alt?nda?, Ankara, Turkey;1. Postgraduate Program in Child and Adolescent Health, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Translational Research Group in Autism Spectrum Disorder (GETTEA), Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;3. Food and NutritionResearch Centre (CESAN), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;4. Postgraduate Program in Collective Health, Academic Unit of Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, Brazil;5. Child Neurology Unit, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;1. University of Michigan Medical School, Ann Arbor, Michigan;2. Pediatrics and Developmental Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland;3. Department of Neurology, New York University, New York, New York;4. Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan;1. Department of Urology, Northwestern Medicine, Chicago, Illinois;2. Urology Service, Department of Surgery, and the Genitourinary Oncology Service, Division of Solid Tumor Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York;3. Department of Urology, University of Iowa Carver College of Medicine, Iowa City, Iowa;1. Division of Developmental Medicine, Department of Neurology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts;2. Lurie Center for Autism, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts;3. Division of Clinical Neurophysiology, Department of Neurology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts;3. Charles Perkins Centre, School of Life and Environmental Sciences, Camperdown, New South Wales 2006, Australia;12. Charles Perkins Centre, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia;4. Vascular Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia;5. St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia;6. School of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom |
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| Abstract: | ![]()
Iron deficiency (ID) cause negative outcomes on psychomotor and behavioral development of infants and young children. Children with autistic spectrum disorders (ASD) are under risk for ID and this condition may increase the severity of psychomotor and behavioral problems, some of which already inherently exist in these children. In the present study, the frequency of ID and the association between ID and autistic symptoms, developmental level, and behavioral problems in preschool children attending a clinic for ASD (N = 31) were evaluated. No association was observed between ID and the severity of autistic symptoms, developmental level and behavioral problems. ID was detected in 32.3% (N = 10) of the children based on serum ferritin level. In this study, the negative impact of low serum ferritin in ASD has not been confirmed. On the other hand, the rate of ID was considerably high in this sample of children with ASD compared to normative data of preschool children. Further studies with larger samples are needed to clarify the relationship between ID and clinical variables associated with ASD. |
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