乙型肝炎性肝癌和酒精相关性肝癌患者外周血中T细胞亚群表达差异和价值

目的:分析乙型肝炎性肝癌(HBV-HCC)和酒精相关性肝癌(ALC-HCC)患者外周血中T细胞亚群表达差异和价值.方法:将2016年07月至2018年10月期间于本院接受诊治的65例乙型肝炎性肝癌患者作为HBV-HCC组,另选择同期于本院接受诊治的58例酒精相关性肝癌患者作为ALC-HCC组.经全自动生化分析仪及流式细...

Differential expression and value of T cell subsets in peripheral blood of patients with hepatitis B and alcohol-related liver cancer

Objective:To analyze the differential expression and value of T cell subsets in peripheral blood of patients with hepatitis B(HBV-HCC)and alcohol-related liver cancer(ALC-HCC).Methods:65 cases of patients with hepatitis B liver cancer who were treated in our hospital from July 2016 to October 2018 were treated as HBV-HCC group.Another 58 cases of patients with alcohol-related liver cancer who were treated in our hospital at the same time were selected as the ALC-HCC group.The T cell subsets were detected by automatic biochemical analyzer and flow cytometry.The Child-Pugh classification of liver function was compared between the two groups.Results:The values of CD3⁺,CD8⁺,CD4⁺CD45RA⁺in peripheral blood of HBV-HCC group were higher than those in ALC-HCC group,but the values of CD4⁺,CD4⁺/CD8⁺,CD4⁺CD25⁺,CD8⁺CD28⁺in peripheral blood were lower than those in ALC-HCC group(P<0.05).Univariate analysis showed that the age,BMI,type of surgery,clinical stage,size of primary lesion,size of vascular invasion and survival time were correlated with the prognosis of patients(P<0.05).Multivariate Logistic regression analysis found that patients aged≥60 years old,BMI>24 kg/m2,open surgery,clinical stage,primary lesion>3.6 cm,vascular invasion and median survival time<72 months were factors influencing prognosis(P<0.05).Conclusion:The expression of T cell subsets in peripheral blood of patients with hepatitis B and alcohol-related liver cancer are significantly different,which can be regarded as an important index for clinical evaluation of the disease progression,efficacy and prognosis of liver cancer patients.