奥沙利铂联合长春瑞滨治疗晚期非小细胞肺癌疗效观察

背景与目的奥沙利铂(OXA)联合长春瑞滨(NO方案)已经在一些实体瘤的治疗中显示出较好的疗效。本研究旨在比较NO方案与顺铂联合长春瑞滨(NP方案)治疗晚期非小细胞肺癌的疗效与毒副反应。方法随机采用NO方案和NP方案治疗晚期非小细胞肺癌患者,3～4周为一个周期,完成2～4周期治疗后评价疗效。结果NO组29例,无CR,PR12例,有效率为41.4%;NP组30例,CR1例,PR13例,有效率为46.7%(P>0.05)。两组毒副作用比较:白细胞下降、静脉炎等毒副反应相似,NP组脱发、胃肠道反应较NO组显著(P<0.05),而NO组神经毒性较NP组显著(P<0.05)。结论两方案治疗晚期非小细胞肺癌近期疗效相近;白细胞下降、静脉炎等毒副反应相似,而两组间胃肠道反应、脱发、神经毒性比较有显著性差异,但均可耐受。

Oxaliplatin combined with vinorelbine in the treatment of patients with advanced non-small cell lung cancer

Background and objective Vinorelbine (NVB) and oxaliplatin (OXA) have shown effective anticancer activity in a wide range of solid tumors. This study is to observe the efficacy and side effects of OXA in combination with NVB in the treatment of advanced non-small cell lung cancer (NSCLC). Methods Fifty-nine patients with NSCLC were randomly treated by OXA+NVB or cisplatin (DDP)+NVB regimen, repeated every 3--4 weeks. They received at least 2 cycles of chemotherapy. Results There were 29 patients treated with NO regimen, in which there was no complete response (CR) patient, 12 patients showed partial response (PR), and the response rate was 41.4%. There were 30 patients treated with NP regimen. One patient showed CR, 13 patients showed PR, and the response rate was 46.7%. There was no significant difference in response rate between the two groups (P>0.05). The major toxicities, including leukopenia and phlebitis, were similar in the two groups. The incidences of gastrointestinal reaction and alopecia of NP regimen were more severe than those of NO regimen (P<0.05), but neurotoxicity of NO regimen was more obvious than that of NP regimen (P<0.05). Conclusion The efficacy of the two regimens are similar in the treatment of advanced NSCLC. The side effects such as leukopenia and phlebitis are similar in the two groups. However, there are significant differences in gastrointestinal reaction, alopecia and neurotoxicity between the two groups. All the toxicities are well tolerable.