| 抗癫痫药物引起代谢性骨病的研究 |
| |
| 引用本文： | 胡孟瑛,王耀红,黎明,侯郁馥,宋金铃,朱秀英,王莉,葛兰波.抗癫痫药物引起代谢性骨病的研究[J].哈尔滨医科大学学报,1991(6). |
| |
| 作者姓名： | 胡孟瑛 王耀红 黎明 侯郁馥 宋金铃 朱秀英 王莉 葛兰波 |
| |
| 作者单位： | 哈尔滨医科大学二院儿内科，哈尔滨医科大学二院儿内科，哈尔滨医科大学二院儿内科，哈尔滨医科大学二院儿内科，哈尔滨医科大学二院儿内科，哈尔滨医科大学临床药物研究所，哈尔滨医科大学临床药物研究所，哈尔滨医科大学临床药物研究所 进修医生，进修医生，进修医生 |
| |
| 摘 要： | 本文对服用抗癫痫药物达1～1.5年的78例患儿进行了治疗药物监测(TDM)、血生化及放射学骨矿含量(BMC)等定量指标的观察研究。结果表明,BMC水平下降,碱性磷酸酶(AKP)活性与治疗呈正相关。当苯巴比妥钠(PBS),丙戊酸钠(SV)的TDM(?)值分别大于18.21mg/ml、74.25mg/ml时,AKP活性增加。
|
| 关 键 词： | 抗癫痫药物 代谢性骨病 骨矿含量 治疗药物监测 |
A Study on Metabolic Osteopathy Caused by Antiepilepsy Drugs |
| |
| Hu Mengying et al.A Study on Metabolic Osteopathy Caused by Antiepilepsy Drugs[J].Journal of Harbin Medical University,1991(6). |
| |
| Authors: | Hu Mengying |
| |
| Abstract: | Treatment determine medicine, biochemistry of blood and content of bone mineral by radiology were studied in 78 sick children who took antiepilepsy drugs for 1-1.5 years. The results showed that contents of bone mineral was lower, there was a positive correlation between AKP activity and phases of treatment. When concentration of phenobarbital sodium and sodium valproate in blood were more than 18.21mg/ml and 74.25mg/ml respectively, AKP activity increased. |
| |
| Keywords: | Antiepilepsy drugs Metabolic osteopathy Content of bone min eral TDM |
| 本文献已被 CNKI 等数据库收录！ |
|
