GPR54和kisspeptins与青春期启动

G蛋白偶联受体54(GPR54)和kisspeptins是哺乳动物体内的两组肽类物质,kisspeptins是 GPR54的配体,二者与青春期启动密切相关。大鼠GPR54突变者不能进入青春期,人类GPR54突变者出现性腺功能低下。动物实验表明,kisspeptins通过GPK54引起促性腺激素释放增加,可能直接作用于下丘脑促黄体激素释放激素神经元水平。

GPR54, kisspeptins and the onset of puberty

GPR54(G-protein-coupled receptor 54) and kisspeptins are two groups of peptides in mammals and kisspeptins are the endogenous ligands of GPR54. Both of them play important roles in the onset of puberty. Mice lacking GPR54 fail to undergo puberty, while patients with loss-of-function mutations in GPR54 have idiopathic hy-pogonadotropic hypogonadism. Animal experiments indicate that kisspeptins increase the release of gonadotropin via GPR54 and probably act directly on the hypothalamic luteinizing hormone-releasing hormone neurons.