中药治疗女性耐药性解脲脲原体疗效观察

目的探讨中药治疗女性耐药性解脲脲原体的临床疗效。方法选取2011年12月至2013年6月我中心门诊及下属站点收治的耐药性解脲脲原体女性患者67例,随机分成观察组34例,对照组33例。对照组给予传统西药口服、外用栓剂治疗,观察组在对照组基础上联合中药进行治疗,比较两组患者的临床疗效。结果观察组转阴率为64.71%显著高于对照组的15.15%,复发率9.09%明显低于对照组的60%（P〈0.05）;观察组解脲脲原体未转阴患者对强力霉素、四环素、交沙霉素、美满霉素、克拉霉素、司巴沙星、氧氟沙星、红霉素、罗红霉素敏感率显著高于对照组（P〈0.05）;观察组不良反应发生率为8.82%,对照组为6.06%,无统计学意义（P〉0.05）。结论联合中药治疗女性耐药性解脲脲原体患者可显著提高转阴率、抗生素敏感性,且具有复发率低,安全性高的特点。

Observation on the efficacy of traditional Chinese medicine in the treatment of female drug resistance of ureaplasma urealyticum

Objective To explore the clinical curative effect of traditional Chinese medicine in the treatment of female drug resistance of Ureaplasma urealyticum. Methods Totally 67 cases of female patients suffered from drug resistance of ureaplasma urealyticum and got therapy in our center clinic or subordinate site during December 2011 and June 2013 were randomly divided into two groups. The control group including 33cases,and 34 cases were included in the treatment group. Patients in the control group were given conventional western medicine orally and suppository for external use,however,patients in the treatment group received traditional Chinese medicine on the bases of the control group,clinical efficacy of the two groups were compared.Results The effective rate of treatment group（ 64. 71%） was significantly higher than that of control group（ 15.15%）,but the recurrence rate was significantly lower than the control group（ 9. 09% vs 60%）（ P〈0. 05）;Sensitive rate on doxycycline,tetracycline,josamycin,minocycline,clarithromycin,sparfloxacin,ofloxacin,erythromycin and roxithromycin of ureaplasma urealyticum patients of the treatment group was significantly higher than the control group（ P〈0. 05）; The incidence of adverse reaction of treatment group was 8. 82%,and it was6. 06% in the control group,the differences present no statistically significant（ P〉0. 05）. Conclusions The combination of traditional Chinese medicine in the treatment of female drug resistance of ureaplasma urealyticum can significantly improve the negative rate and antibiotic sensitivity,low in recurrence rate and high in security.