乌司他丁治疗急性胰腺炎65例疗效观察

目的：观察乌司他丁治疗急性胰腺炎（AP）的临床疗效及安全性。方法：将131例AP患者随机分为治疗组65例和对照组66例，两组均给予常规治疗，治疗组在此基础上加用乌司他丁治疗。结果：①治疗组轻症的总有效率为100％，与对照组（总有效率为97．2％）比较无显著性差异（P〉0．05），但治疗组轻症的痊愈率（73．5％）则显著优于对照组的47．2％（P〈0．05）。②治疗组重症的总有效率为87．1％，对照组重症的总有效率为63.3％，两者比较差异有显著性（P〈0.05），治疗组重症的痊愈率（61.3％）也显著优于对照组（33.3％）（P〈0．05）。治疗组发生并发症的比率（6．5％）显著低于对照组（26．7％）（P〈0．05），且未见明显副作用。结论：早期使用乌司他丁对AP有明显的抑制作用，且无明显不良反应。

Observation on ulinastatin in treatment of 65 cases with acute pancreatitis

Objective： To observe the effect of ulinastatin in treating acute pancreatitis （AP） and its safety. Methods： 131 cases with AP were randomly divided into treatment group and control group. Two group received routine treatment. In addition, the treatment group were given ulinastatin for five to ten days. Results：①There was not significant difference in total effectiveness rate between two groups in light type（100% vs 97.2%, P〉0.05）, but the cured rate of treatment group in light type was significantly higher than that of control group （73.5% vs 47.2%, P〈0.05）. ②The total effectiveness rate of treatment group in severe type was significantly higher than that of control group （87.1% vs 63.3%, P〈0.05）, the cured rate of treatment group in severe type was significantly higher than that of control group too （61.3% vs 33.3%, P〈0.05）. The rate of complication in treatment group was significantly lower than that of control group （6.5% vs26.7%, P〈0.05）, and had few side effects occurred. Conclusion： Ulinastatin can evidently inhabit AP in early stage without obvious side effects.