系统性红斑狼疮患者血清sICAM-1和IL-12的变化

目的 探讨活动期和稳定期系统性红斑狼疮（ＳＬＥ）患者血清中的可溶性胞间粘连分子－１（ｓＩＣＡＭ－１）和白细胞介素１２（ＩＬ－１２）的变化及其意义。方法 应用ＥＬＩＳＡ法测定１６例活动期、１５例稳定期及２０例健康者血清中要和ＩＬ－１２水平，并与抗－ｄｓＤＮＡ，抗核抗体（ＡＮＡ），血沉等进行相关分析。结果 与对照组比较，稳定期和活动期口才血清中ＩＬ－１２水平依次降低；ＳＬＥ患者血清中ｓＩＣＡＭ－１水平

Changes of sICAM-1 AND IL-12 in Systemic Lupus Erythematosus Patients

To investigate the changes of levels of soluble intercellular adhesion molecule 1(sICAM 1) and interleukin 12(IL 12) in sera of active and inactive systemic lupus erythermatosus(SLE) patients \ Methods\ Sera from 16 active and 15 inactive SLE patients and 20 normal controls were tested for sICAM 1 and IL 12 \ The correlation of anti dsDNA, antinuclear autibody(ANA) ,erythrocyte sedimentation rate( ESR) and sICAM 1 or IL 12 was studied,respectively \ Results\ Sera levels of IL 12 in inactive and active SLE patients were in turn significantly decreased when compared with normal controls(P<0 01) \ Sera levels of sICAM 1 in SLE patients was significantly elevated when compared to normal controls (P<0 01), but no significant difference between active and inactive SLE patients was noted \ The changes of anti dsDNA, ANA, ESR in SLE patients correlated well with IL 12, but correlated poorly with sICAM 1 \ Conclusion\ IL 12 plays an important role in the mechanism of immune mediated injury and disease occurrence of SLE, and sICAM 1 may be used as one of the detecting methods for SLE