| PCNA和C-erbB-2在大肠癌组织中的表达及其意义 |
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| 引用本文： | 张闽峰,刘会发,林福地,孟家榕,郭以河. PCNA和C-erbB-2在大肠癌组织中的表达及其意义[J]. 临床肿瘤学杂志, 2002, 7(2): 85-87,90 |
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| 作者姓名： | 张闽峰 刘会发 林福地 孟家榕 郭以河 |
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| 作者单位： | 363000,福建漳州,解放军第175医院病理科;363000,福建漳州,解放军第175医院病理科;363000,福建漳州,解放军第175医院病理科;363000,福建漳州,解放军第175医院病理科;363000,福建漳州,解放军第175医院病理科 |
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| 摘 要： | 目的：探讨PCNA和C－erbB-2在大肠癌发病中的作用及其与病理分级,临床分期及预后的关系。方法：应用免疫组化SP地对52例大肠癌组织及癌旁粘膜进行检测。结果：PCNA和C-erbB－2在大肠癌组织均呈高表达（P＜0．05）;与病理分级、临床分期及预后密切相关。结论：PCNA和C－erbB－2在大肠癌的发生和发展过程中起重要作用,提示PCNA和C－ erbB-2可作为判断大肠癌预后的标记物。
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| 关 键 词： | 大肠肿瘤 C-erbB-2 增殖细胞核抗原(PCNA) 免疫组化 |
| 文章编号： | 1009-0460(2002)02-0086-03 |
Expression of PCNA and C-erbB-2 proteins in large intestine cancer |
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| Zhang Minfeng,Liu Huifa,Lin Fudi,et al.. Expression of PCNA and C-erbB-2 proteins in large intestine cancer[J]. Chinese Clinical Oncology, 2002, 7(2): 85-87,90 |
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| Authors: | Zhang Minfeng Liu Huifa Lin Fudi et al. |
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| Affiliation: | Zhang Minfeng,Liu Huifa,Lin Fudi,et al.Department of pathology,the 175th Hospital of PLA,Fujan 363000 |
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| Abstract: | Objective:To investigate the roles of PCNA and C-erbB-2 proteins in the development of large intestine cancer and their relationships with pathological grade,clinic stage and prognosis.Methods:The immunohistochemical methods were adopted to examine the expression of PCNA and C-erbB-2 proteins in 52 cases with large intestine cancer and normal mucosa of paracancer.Results:Overexpression of PCNA and C-erbB-2 proteins were found in large intestine cancer( P <0 05);Their expression were closely association with tumor grades,stages and prognosis respectively.Conclusion:PCNA and C-erbB-2 proteins may play important roles in the development and progression of large intestine cancer.PCNA and C-erbB-2 proteins may be valuable markers for the evaluation of large intestine cancer prognosis. |
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| Keywords: | Large intestine neoplasm C-erbB-2 proteins Proliferating cell nuclear antigen Immunohistochemistry |
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