与川崎病发病及冠状动脉损伤相关的易感基因

川崎病(KD)是婴幼儿时期的急性血管炎，已成为发达国家儿童获得性心脏病最常见的原因，可导致冠状动脉病变而出现心肌缺血﹑梗死甚至死亡。尽管近50多年的研究，然而其病因和发病机制尚不完全清楚。目前关于KD的研究多集中于遗传易感性和免疫发病机理。好发于亚裔人群和一级亲属患病率高表明遗传因素与KD的易感性有关。本文概述了与川崎病发病及冠状动脉损伤相关基因的最新研究进展。

Association of Susceptibility Genes with Kawasaki Disease and Coronary Artery Lesion

Kawasaki disease (KD) is an acute vasculitis of infancy and childhood that has become the leading cause of ac-quired heart disease in children in the developed world, in whom the resulting coronary artery abnormalities can cause my-ocardial ischaemia, infarction and even death. The etiology and pathogenesis of KD have yet to be known despite more than 5 decades of investigation. Recent advances in research on KD include searches for genetic susceptibility related to KD and research on immunopathogenesis. Genetic factors increase susceptibility to Kawasaki disease, as indicated by its strikingly high incidence rate in children of Asian ethnicity and by an increased incidence in first-degree family members. This re-view summarizes recent advances in understanding of the susceptibility genes related to Kawasaki disease and coronary artery lesion.