阿托伐他汀联合阿司匹林治疗短暂性脑缺血发作的有效性与安全性

目的：探讨短暂性脑缺血发作(TIA）应用阿托伐他汀(Ato）联合阿司匹林治疗的有效性与安全性。方法整群选取该院2015年1月一2016年1月收治的86例TIA患者,按随机数字表法均分为两组。对照组43例,给予常规综合治疗；观察组43例,在此基础上联合Ato治疗。记录比较两组治疗结束后临床疗效,治疗前后血清甘油三酯(TG）、低密度脂蛋白(LDL）及总胆固醇(TG）水平,治疗期间不良反应。结果观察组总有效率为93.02%较对照组的76.74%明显更高(P<0.05）；治疗后观察组血清TG、LDL及TC水平分别为(1.92±0.57）、(3.49±0.52）、(5.12±0.62）mmol/L,对照组依次为(2.58±0.61）、(4.25±0.57）、(5.47±0.59）mmol/L,均明显低于本组治疗前(P<0.05）,且观察组较对照组改善程度更为明显(P<0.05）；两组不良反应比较,差异无统计学意义(P>0.05）。结论TIA应用Ato联合阿司匹林治疗更能有效改善血脂水平,疗效显著且安全可靠,具有较高临床指导意义。

Efficacy and Safety of Atorvastatin Combined with Aspirin in the Treatment of Transient Ischemic Attack

Objective To investigate the efficacy and safety of atorvastatin (Ato) combined with aspirin applied in the treat-ment of transient ischemic attack(TIA). Methods Group selection 86 cases of TIA patients treated in our hospital from Jan-uary 2015 to January 2016 were selected and divided into two groups with the method of random number table. 43 cases in the control group, were given routine combined therapy; 43 cases in the observation group on the basis of which was com-bined with Ato. The clinical efficacy, the serum triglyceride (TG), low density lipoprotein(LDL), total cholesterol(TG) levels before and after the treatment and the adverse reactions during the treatment period of the two groups were recorded and compared. Results The total effective rate of observation group was 93.02%, compared with 76.74% of control group, which was significantly higher(P<0.05); After treatment the serum levels of TG, LDL and TC of the observation group were (1.92± 0.57)mmol/L, (3.49±0.52)mmol/L, (5.12±0.62)mmol/L, the control group were (2.58±0.61)mmol/L, (4.25±0.57)mmol/L, (5.47± 0.59)mmol/L, were significantly lower than those in the group before treatment (P<0.05). And the improvement degree in the observation group was more obvious when compared with that of the control group (P<0.05);the adverse reactions of the two groups were compared, and the difference was not statistically significant(P>0.05). Conclusion The application of Ato in the treatment of TIA combined with aspirin therapy can effectively improve blood lipid level, with significant efficacy safely and reliably, witch has a higher clinical significance.