羟考酮注射液对胃癌手术患者全麻后在恢复室的应用

目的：探讨盐酸羟考酮注射液对上腹部手术患者全身麻醉后入恢复室（PACU)中的应用。方法方便选择2013年3月—2015年5月该院实施胃癌手术患者80例，ASAⅠ~Ⅱ级。实施同样的麻醉方案，术毕所有患者转入PACU。由PACU医师随机分为盐酸羟考酮注射液组（A组，n=40)和硫酸吗啡注射液组（B组，n=40)，接注射泵（0.9%生理盐水将两种药物稀释至1 mg/mL)按1 mg/kg泵入。由PACU医师观察并记录患者拔管前5 min、拔管时及拔管后15 min的MAP、HR、SPO2及拔管后恶心呕吐等不良反应。结果与B组比较，A组拔管前后的MAP（128.6±11.2)、HR（90.3±4.1)、SPO2（77.6±11.0)较平稳且差异有统计学意义（P﹤0.05)。拔管后统计的各种不良反应的总数A组较B组明显偏少且差异有统计学意义（P﹤0.05)。拔管后5min、15 min、30 min的VRS痛觉评分两组比较差异无统计学意义（P>0.05)。期间2组均未发生严重不良反应，且所有患者在PACU中过程基本平稳，顺利出室。结论盐酸羟考酮注射液对胃癌手术患者在PACU中应用安全有效，镇痛效果与吗啡相当，但较吗啡使用后血流动力学更平稳，拔管后恶心、呕吐等不良反应发生率更低。

Oxycodone Injection on Patients Undergoing Surgery for Gastric Cancer af-ter Application in the Recovery Room

Objective To investigate the oxycodone hydrochloride injection of anesthesia for upper abdominal surgery pa-tients in recovery unit (PACU) application.Methods 80 cases of gastric cancer patients from March 2013 to May 2015 un-dergoing elective operation, ASA I ~ II. Implementation of the same anesthetic regimens and postoperative all patients into four by the PACU doctors were randomly divided into oxycodone hydrochloride injection group (group A, n=40) and mor-phine sulfate injection group (group B, n=40) and access injection pump (0.9% saline will two drugs diluted to 1 mg/mL) 1 mg/kg pump into. By the PACU physician observed and recorded the pull tube before 5min, extubation time and extuba-tion after 15min of map, HR, SPO2 and extubation after nausea, vomiting and other adverse reactions. Results Compared with the B group, the A group of MAP (128.6 ± 11.2), HR (90.3 ±4.1) SPO2 (77.6± 11) (P﹤ 0.05), before and after extuba-tion. The total number of adverse reactions after extubation was significantly less than that in group A (P﹤ 0.05). There was no significant difference in pain scores of 5min, 15 min and VRS in two groups after extubation (P>0.05) (30min). No seri-ous adverse reactions occurred during the 2 groups, and all patients in the process of PACU basically stable, smooth out of the room. Conclusion Oxycodone hydrochloride injection on patients with gastric carcinoma in the PACU application secu-rity effectively, and the analgesic effect of morphine quite, but is the use of morphine hemodynamics more stable, after ex-tubation, nausea, vomiting and other adverse reactions occurred rate is lower.