军蛭煎剂对小鼠胸腺、脾脏重量指数及组织结构影响的实验研究

目的：探讨军蛭煎剂对小鼠胸腺、脾脏重量指数及脾脏组织结构的影响。方法：将昆明种6月龄小鼠60只随机分为正常对照组、模型组、VE胶丸组（20mg／kg）、军蛭煎剂大剂量组（56．8mg／kg）、军蛭煎剂中剂量组（28．4mg／kg）、军蛭煎剂小剂量组（14．2mv,／kg）。模型组和给药组每天腹腔注射D-半乳糖125mg／kg，正常组注射等量生理盐水，连续注射5W.5W后取材，称重，制备光镜标本。用电子天平称胸腺、脾脏湿重，以每10g体重中胸腺或脾脏所占重量（mg／10g）表示胸腺、脾脏重量指数。结果：与模型组比较，军蛭煎剂各剂量组和VE胶丸组小鼠脾指数和胸腺指数增加，脾脏显微结构改善。结论：军蛭煎剂具有改善D-半乳糖致衰小鼠免疫器官结构的形态学损坏，提高免疫器官重量指数的作用。

Experimental Study of Junzhi Jianji on Weight Indices of Immune Organs and Histological Structure of Spleen of Aging Mice

Objective:To observe the effect of Junzhi Jianji on weight indices of thymus gland and spleen and histological structure of spleen of aging mice.Methods:60 Kunming mice of 6 months were divided into 6 groups randomly:control group,model group,VE group,Junzhi Jianji group 1(high dosage),group 2(middle dosage),group 3(low dosage).Demencia model mice were made by intraperitoneally injecting D-glacatose once a day for successive 5 w,while the mice in control group were injected with the same amount of physiological saline.5 w later,the weights of spleen and thymus gland of mice were measured,histological structure of spleen was observed by light microscope.Result:Compared with model group,weight indices of spleen and thymus gland were increased and morphology impairment of histological structure of spleen was improved in every treatment group.Conclusion:Junzhi Jianji could increase weight indices of immune organs and improve morphology impairment of histological structure of spleen.