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| Caspase-3和P53在胃癌中的表达及临床意义 | |
| 引用本文： | 谢琼,卢月月,易宏锋.Caspase-3和P53在胃癌中的表达及临床意义[J].胃肠病学和肝病学杂志,2014,23(11):1287-1289. |
| 作者姓名： | 谢琼 卢月月 易宏锋 |
| 作者单位： | 1. 荆州市第一人民医院内分泌一科,湖北荆州,434000 2. 荆州市第一人民医院消化二科,湖北荆州,434000 3. 荆州市第一人民医院消化一科,湖北荆州,434000 |
| 摘 要： | 目的通过检测Caspase-3和P53在胃癌组织及正常胃黏膜组织中的表达情况,探讨两者与胃癌发生、发展的关系。方法采用免疫组化SP法检测胃癌组织及正常胃黏膜组织中两者的表达情况。结果胃癌组织及正常胃黏膜组织中,Caspase-3的表达阳性率分别为30.0%(15/50)、70.0%(14/20),差异有统计学意义(P0.05);P53在胃癌组织及正常胃黏膜中表达阳性率分别为76.0%(38/50)、25.0%(5/20),差异有统计学意义(P0.05);Caspase-3和P53的阳性表达率与胃癌的浸润深度、分化程度、淋巴结转移密切相关。结论 Caspase-3和P53与胃癌的发生及发展密切相关。 |
| 关 键 词： | 胃癌 正常胃黏膜 Caspase-3 P53 |
Expression and clinical significance of Caspase-3 and P53 in gastric cancer |
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| XIE Qiong,LU Yueyue,YI Hongfeng.Expression and clinical significance of Caspase-3 and P53 in gastric cancer[J].Chinese Journal of Gastroenterology and Hepatology,2014,23(11):1287-1289. | |
| Authors: | XIE Qiong LU Yueyue YI Hongfeng |
| Institution: | XIE Qiong,LU Yueyue,YI Hongfeng(1.Department of NO.1 Endocrine,the First People＇s Hospital in Jingzhou, Jingzhou 434000, China;2.Department of NO.2 Gastroenterology,the First People＇s Hospital in Jingzhou, Jingzhou 434000, China;3.Department of NO.1 Gastroenterolgy,the First People＇s Hospital in Jingzhou, Jingzhou 434000, China) |
| Abstract: | Objective To detect the expression of Caspase-3 and P53 in gastric cance tissue and normal gastric mucosa tissue,and investigate the relationship between Caspase-3,P53 and the occurrence,development of gastric cancer.Methods The expression of Caspase-3 and P53 in gastric cancer tissues and normal gastric mucosa tissues were detected by SP immunohistochemical.Results The expression of Caspase-3 positive rate in gastric cancer tissue was 30.0％ （15/50）,in normal gastric mucosa was 70.0％ （14/20）,there was significantly difference （P ＜ 0.05）.The positive rate of P53 in gastric cancer tissues was 76.0％ （38/50）,in normal gastric mucosa was 25.0％ （5/20）,there was significantly difference （P ＜ 0.05）.The positive rate of Caspase-3 and P53 were closely related to the depth of invasion,differentiation,lymph node metastasis of gastric cancer.Conclusion Caspase-3 and P53 are closely related to the occurrence and development of gastric cancer. |
| Keywords: | Gastric cancer Normal gastric mucosa Caspase-3 P53 |
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