曲美他嗪对冠心病心力衰竭患者心肌功能与相关免疫指标的影响

目的:探讨曲美他嗪对冠心病心力衰竭患者心肌功能与相关免疫指标的影响。方法:选择2014年2月至2015年4月在川北医学院附属医院心内科进行治疗的冠心病合并心力衰竭患者107例,按随机数字表法分为观察组54例和对照组53例。对照组使用常规治疗。观察组在常规治疗的基础上应用曲美他嗪,每日给药3次,每次给药20 mg。结果:观察组患者总有效率显著高于对照组[92.6%(50/54)vs.73.6%(39/53),P<0.05]。治疗后,观察组患者左心室射血分数,6 min内步行距离显著高于对照组(P<0.05);观察组左心室舒张末期内径、左心室收缩末期内径显著低于对照组(P<0.05)。观察组患者NK细胞水平显著高于对照组[(15.3±3.2)vs.(13.2±3.5),P<0.05],观察组患者Ig G水平显著高于对照组[(4.8±0.8)vs.(3.1±1.3),P<0.05]。结论:曲美他嗪能够显著改善冠心病心力衰竭患者的心肌功能,同时能够增强机体免疫力,改善心衰患者预后。

Effect of trimetazidine on cardiac function and heart failure related im-mune indexes in patients with coronary heart disease

Objective:To study the effect of trimetazidine on myocardial function in patients with coronary heart disease and heart failure related immune indexes.Methods:107 patients with coronary heart disease complicated with heart failure treated in depart-ment of cardiology,Affiliated Hospital of North Sichuan Medical College,Nanchong City from February 2014 to April 2015.They were divided into observation group(54)and control group(53)according to random number table method.The control group was treated with conventional treatment.The observation group treated with trimetazidine based on conventional treatment,the dosage of trimetazidine was 20 mg each time,3 times a day.Results:The total efficiency of observation group was significantly higher than the control group [92.6%(50 /54)vs.73.6%(39 /53),P <0.05].After treatment,the left ventricular ejection fraction and 6min walking distance in the observation group were significantly higher than those in the control group (P <0.05 ).The left ventricular end diastolic diameter and left ventricular end systolic diameter in the observation group were significantly lower than those in the control group (P <0.05). The level of NK cells in observation group was significantly higher than that in control group [(15.3 ±3.2)vs.(13.2 ±3.5 ),P <0.05],and the level of IgG in observation group was significantly higher than that in control group [(4.8 ±0.8)vs.(3.1 ±1 .3),P <0.05].Conclusion:Trimetazidine can significantly improved myocardial function in patients with heart failure of coronary heart dis-ease,at the same time,to enhance immunity and improve prognosis of patients with coronary heart disease.