| 复方氨酚烷胺胶囊中对乙酰氨基酚的溶出度测定方法探讨 |
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| 引用本文： | 周泉,卢小兰,李全良,黄富宏. 复方氨酚烷胺胶囊中对乙酰氨基酚的溶出度测定方法探讨[J]. 中国药业, 2014, 0(24): 85-86 |
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| 作者姓名： | 周泉 卢小兰 李全良 黄富宏 |
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| 作者单位： | 江苏省扬州市第一人民医院,江苏扬州225009 |
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| 摘 要： | 目的建立复方氨酚烷胺胶囊中对乙酰氨基酚的溶出度测定方法。方法采用转篮法,以0.1 mol/L盐酸溶液为溶出介质,转速为100 r/min,30 min时取样,在257 nm波长处测定紫外吸光度。结果对乙酰氨基酚质量浓度在0.500 2-50.02μg/m L范围内与吸光度值线性关系良好,线性回归方程为A=71.486C＋0.6992（r=1.0000）,平均回收率为101.31%,RSD为0.72%（n=6）。结论该方法操作简单,结果准确,可作为该制剂的溶出度测定方法。
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| 关 键 词： | 复方氨酚烷胺胶囊 对乙酰氨基酚 溶出度 紫外分光光度法 |
Investigation on Determination Method of Acetaminophen Solubility in Compound Paracetamol and Amantadine Hydrochloride Capsules |
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| Zhou Quan,Lu Xiaolan,Li Quanliang,Huang Fuhong. Investigation on Determination Method of Acetaminophen Solubility in Compound Paracetamol and Amantadine Hydrochloride Capsules[J]. China Pharmaceuticals, 2014, 0(24): 85-86 |
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| Authors: | Zhou Quan Lu Xiaolan Li Quanliang Huang Fuhong |
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| Affiliation: | (Yangzhou Municipal First People＇s Hospital, Yangzhou, Jiangsu, China 225009) |
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| Abstract: | Objective To establish the solubility determination method of acetaminophen in Compound Paracetamol and Amantadine Hydrochloride Capsules. Methods The rotating basket method was adopted with 0. 1 mol/L hydrochloric acid solution as the dissolution medium. The sample was extracted at a rotating speed of 100 r/min and the ultraviolet absorbance was detected at the wavelength of257 nm. Results The mass concentration range of acetaminophen in the range of 0. 500 2- 50. 02 μg/m L showed good linear relationship with the peak area,the linear equation was A = 71. 486 C ＋ 0. 699 2（r = 1. 000 0）. The average recovery rate was101. 31%,RSD 0. 72%（n = 6）. Conclusion This method is simple to operate and accurate in results,which can be used as the solubility determination method of this preparation |
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| Keywords: | Compound Paracetamol and Amantadine Hydrochloride Capsules Acetaminophen Dissolution Uv speetrophotometry |
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