| 二羰基化合物与糖尿病慢性并发症关系的研究进展 |
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| 引用本文： | 王倩,江国荣,王纯庠. 二羰基化合物与糖尿病慢性并发症关系的研究进展[J]. 安徽医药, 2010, 14(2): 130-133. DOI: 10.3969/j.issn.1009-6469.2010.02.003 |
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| 作者姓名： | 王倩 江国荣 王纯庠 |
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| 作者单位： | 南京中医药大学,江苏,南京,210029;南京中医药大学附属苏州中医医院中医药研究所,江苏,苏州,215003 |
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| 摘 要： | 二羰基化合物是一种高反应性毒性化合物,近年来研究表明,糖尿病患者体内二羰基化合物水平增高,且由于其本身的毒性作用及快速生成晚期糖基化终产物（advanced glycation end products,AGEs）特性,与糖尿病慢性并发症有一定的关系。本文以甲基乙二醛（methylglyoxal,MGO）、3-脱氧葡萄糖醛酮（3-dexoyglucosone,3-DG）为例,将二羰基化合物的生成代谢及其与糖尿病慢性并发症的关系作一综述。
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| 关 键 词： | 二羰基化合物 甲基乙二醛 3-脱氧葡萄糖醛酮 晚期糖基化终产物 糖尿病慢性并发症 |
Advances of dicarbonyl compounds and diabetes chronic complications |
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| WANG Qian,JIANG Guo-rong,WANG Chun-xiang. Advances of dicarbonyl compounds and diabetes chronic complications[J]. Anhui Medical and Pharmaceutical Journal, 2010, 14(2): 130-133. DOI: 10.3969/j.issn.1009-6469.2010.02.003 |
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| Authors: | WANG Qian JIANG Guo-rong WANG Chun-xiang |
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| Affiliation: | 1.Nanjing University of TCM;Nanjing 210029;China;2 Suzhou Traditional Chinese Medical Research Institute;The Affiliated Suzhou Hospital of TCM of Nanjing University of TCM;Suzhou 215003;China |
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| Abstract: | Dicarbonyl compounds are high reactive toxical compounds.For the past few years,more and more studies indicate that the levels of dicarbonyl compounds are elevated in diabetic patients.There are relationships between dicarbonyls and diabetes complications because of the toxicity and formation of advanced glycation products(AGEs).This paper reviews the metabolism of carbonyls and its relationship with diabetes chronic complications. |
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| Keywords: | carbonyl compounds methylglyoxal 3-deoxyglucosone advanced glycation products diabetes complications |
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