| 慢性脑缺血大鼠EphA4表达变化的研究 |
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| 引用本文： | 李俊敏,张博爱,贾延劼,马建法,刘艳茹,高林.慢性脑缺血大鼠EphA4表达变化的研究[J].中国现代医学杂志,2008,18(15):2113-2116,2121. |
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| 作者姓名： | 李俊敏 张博爱 贾延劼 马建法 刘艳茹 高林 |
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| 作者单位： | 郑州大学第一附属医院,神经内科,河南,郑州,450052 |
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| 摘 要： | 目的 探讨大鼠海马区及皮层EphA4表达在慢性脑缺血的不同时间点的动态变化.方法 大鼠随机分为正常组、假手术组、15 d、30 d和60 d模型组.采用双侧颈总动脉永久结扎建立慢性脑缺血模型:Morris水迷宫试验检测行为学变化:免疫组化染色检测EphA4的表达变化.结果 EphA4免疫反应阳性细胞数模型组比假手术组均增多(P<0.05>,与行为学改善基本相符.结论 慢性脑缺血造成EphA4表达持续升高可能是成年哺乳动物损伤后神经再生障碍的重要原因之一.
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| 关 键 词： | 慢性脑缺血 再生 |
Study on expression of EphA4 in senile rat brain after chronic cerebral ischemia |
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| LI Jun-min,ZHANG Bo-ai,JIA Yan-jie,MA Jian-fa,LIU Yan-ru,GAO Lin.Study on expression of EphA4 in senile rat brain after chronic cerebral ischemia[J].China Journal of Modern Medicine,2008,18(15):2113-2116,2121. |
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| Authors: | LI Jun-min ZHANG Bo-ai JIA Yan-jie MA Jian-fa LIU Yan-ru GAO Lin |
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| Institution: | LI Jun-min,ZHANG Bo-ai,JIA Yan-jie,MA Jian-fa,LIU Yan-ru,GAO Lin (Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,P.R.China) |
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| Abstract: | Objectives] To explore the dynamic changes of EphA4 expression in the cortex and hippocampus after chronic cerebral ischemia in rats. Methods] The rats were divided into five groups randomly: normal group, sham operation group, 15 day, 30 day and 60 day model groups. The chronic cerebral ischemic models were produced by the permanent occlusion of bilateral common carotid arteries. All of the rats were trained in Morris Water Maze to find the changes of etiology. The expression of EphA4 was measured by imm... |
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| Keywords: | EphA4 EphA4 chronic cerebral ischemia regeneration |
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