磷酸哌喹用于人群疟疾预防服药的副反应调查

目的分析服用磷酸哌喹人群中预防疟疾副反应的发生频率和类型及其相关因素，探讨减少服药后副反应的措施，为今后调整改进磷酸哌喹使用方案提供依据。方法2007年7-9月在安徽省蒙城县对240名服用磷酸哌喹预防疟疾的村民进行问卷调查，调查分3次在每月的预防服药结束后两日内进行。结果调查对象中副反应发生率为43．3％（103／238），以轻微头晕、恶心和口周脸颊发麻的表现为主；其中，90．2％的人在服药后2h内出现症状（体征），有90．3％的人在24h以内消退；发生副反应的人群中，不同年龄组无差别。女性高于男性。空腹服药者高于非空腹服药者。结论磷酸哌喹的副反应发生率相对较高，但均轻微，持续时间短，对生活生产不构成影响，餐后服药利于减少副反应的发生。

Analysis of side effects caused by piperaquine phosphate for malaria prophylaxis in population

Objective To observe the types of side effects caused by plperaquine phosphate in population of drug prophy- laxis and analyze the relationship between side effects, relevent factors （age, gender, dosing time, etc）, the time distributions of side effects and discuss the measures to reduce side effects. Methods From July to September, 2007, A questionnaire survey of side effect in population of Mengcheng, Anhui province once a month in 2 days just after each administration of piperaquine phosphate for drug prophylaxis. Results （1） Overall side effect incidence rate was 43.3% and the main manifes- tations were slight dizziness, nausea and cheeks anesthesia, and there was no difference between age groups in side effect inci- dence rate; （2）Side effect incidence rate was higher in females than that of males. Side effect incidence rate was higher in those taken with empty stomach; （3）90.2% of the side effects occurred within 2 hours after taking piperaquine phosphate, and 90.35% recovered in 24 hours. Conclusion Overall side effect incidence rate is relatively high, but most of them are slight and would not last for too long, it would not affect people＇ s life and the side effects can be minimized if piperaquine phosphate is taken after meal.