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| 宫颈脱落细胞高危人乳头瘤病毒DNA分型定量的临床应用 | |
| 引用本文： | 杨秀,童红莉,朱智慧,邓心新,田亚平,温新宇. 宫颈脱落细胞高危人乳头瘤病毒DNA分型定量的临床应用[J]. 军医进修学院学报, 2011, 32(8): 820-821,824. DOI: CNKI:11-3275/R.20110422.1625.008 |
| 作者姓名： | 杨秀 童红莉 朱智慧 邓心新 田亚平 温新宇 |
| 作者单位： | 解放军总医院,生化科,北京,100853 |
| 基金项目： | 国家科技支撑计划项目(2009BAI86B05)~~ |
| 摘 要： | 目的探讨宫颈脱落细胞高危人乳头瘤病毒DNA（HR-HPV-DNA）分型定量在宫颈癌防治中的意义。方法采用实时定量PCR-双色荧光探针法,对1 417例体检妇女进行宫颈脱落细胞作HR-HPV-DNA分型定量检测和TCT检测。结果 HR-HPV16是HR-HPV单型别中阳性率最高的型别（19.14%）。HR-HPV-DNA总体阳性率为13.76%,HR-HPV-DNA阳性率和水平随着细胞学诊断的严重程度增加而升高。在宫颈上皮内瘤变（CIN）组,HR-HPV-DNA水平高于正常组、萎缩性鳞状上皮细胞组、轻度炎症组和中度炎症组（P〈0.05）。非典型鳞状上皮细胞组HR-HPV-DNA水平高于轻度炎症组（P〈0.05）。结论细胞学诊断的严重程度不仅与HR-HPV的型别有关,还与HR-HPV-DNA的水平有关。 |
| 关 键 词： | 高危人乳头瘤病毒 宫颈癌 宫颈脱落细胞 DNA分型 |
Clinical application of high risk-human papillom virus-DNA typing and quantification in exfoliated cervical cells |
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| YANG Xiu,TONG Hong-li,ZHU Zhi-hui,DENG Xin-xin,TIAN Ya-ping,WEN Xin-yu. Clinical application of high risk-human papillom virus-DNA typing and quantification in exfoliated cervical cells[J]. Academic Journal of Pla Postgraduate Medical School, 2011, 32(8): 820-821,824. DOI: CNKI:11-3275/R.20110422.1625.008 | |
| Authors: | YANG Xiu TONG Hong-li ZHU Zhi-hui DENG Xin-xin TIAN Ya-ping WEN Xin-yu |
| Affiliation: | YANG Xiu,TONG Hong-li,ZHU Zhi-hui,DENG Xin-xin,TIAN Ya-ping,WEN Xin-yu Department of Clinical Biochemistry,Chinese PLA General Hospital,Beijing 100853,China |
| Abstract: | Objective To study the significance of high risk-human papillom virus-DNA(HR-HPV-DNA) typing and quantification in prevention and treatment of cervical cancer.Methods HR-HPV-DNA was typed and quantified was detected in exfoliated cervical cells from 1 417 normal females by real-time dual fluorescent probes PCR and 1 417 cases were detected using TCT.Results The positive rate of HR-HPV16 was the highest in all types of HR-HPV,accounting for 19.14%.The total positive rate of HR-HPV-DNA was 13.76%,which increa... |
| Keywords: | HR-HPV-DNA Cervical Cancer Cervical Exfoliated Cells DNA Typing |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |