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| 受体介导的反义治疗研究 | |
| 引用本文： | 张春. 受体介导的反义治疗研究[J]. 国际放射医学核医学杂志, 2000, 24(3): 104-106 |
| 作者姓名： | 张春 |
| 作者单位： | 610041 成都, 华西医科大学附一院核医学科 |
| 基金项目： | 国家自然科学基金! ( 3 9870 2 0 0 ) |
| 摘 要： | 受体介导的反义治疗是利用受体与配体高特异性、高亲和力结合的特点,通过受体介导的内吞作用,将配体与反义寡核苷酸(ASON)形成的转运复合物靶向运送到特定的细胞,使细胞内的ASON达到足够高的浓度,从而有效发挥反义抑制作用。本文简要综述对受体介导的反义治疗日前常用的受体、转运复合物的形成、内吞过程中需要解决的问题及实验研究进展。 |
| 关 键 词： | 受体 反义治疗 反义寡核苷酸 |
| 收稿时间： | 2000-02-06 |
Receptor-mediated antisense therapy studies |
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| Zhang Chun. Receptor-mediated antisense therapy studies[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2000, 24(3): 104-106 | |
| Authors: | Zhang Chun |
| Affiliation: | Department of Nuclear Medicine the Affilated Hospital the West China University of Medical Sciences Sichuan Chengdu 610041, China |
| Abstract: | Receptor can specifically bind its ligand with high affinyty.Based on this antisense oligonucleotides(ONs) linked to specific receptor ligand can be targeted to cells which possess specific receptor and enter into these cells by receptor mediated endocytosis.Adequate intracellular concentrations of antisense ONs can be obtained enough to inhibit target gene expression. Receptors used frequently, formation of ONs delivery complexes, questions required to settle in the process of endocytosis and experiment studies of receptor mediated antisense therapy are concisely introduced in this article. |
| Keywords: | receptor antisense therapy oligonuclides |
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