| 钙调素拮抗剂对非酶体系中羟自由基水平影响的研究 |
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| 引用本文： | 唐磊,胡卓逸.钙调素拮抗剂对非酶体系中羟自由基水平影响的研究[J].中国药科大学学报,1993(6). |
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| 作者姓名： | 唐磊 胡卓逸 |
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| 作者单位： | 中国药科大学生物化学研究室
(唐磊)，中国药科大学生物化学研究室(胡卓逸) |
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| 摘 要： | 研究了钙调素拮抗剂(Calmodulin Antagonist,简写CaM A)与抗坏血酸体系产生的羟自由基(~.OH)的相互作用。结果显示,小檗胺(E_0)及其衍生物(E_5、E_6)、蝙蝠葛碱(D_1)及氯丙嗪(CPZ)在高浓度时均有清除~.OH的作用;除E_0和CPZ外,其它药物在低浓度均可促进~.OH的生成。研究表明,研究钙调素(CaM)与自由基的相互关系时,在合理的浓度范围内使用CaM A作为研究手段是可行的。
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| 关 键 词： | 钙调素拮抗剂 非酶反应体系 羟自由基 小檗胺衍生物 蝙蝠葛碱衍生物 酚噻嗪衍生物 |
Effect of Calmodulin Antagonists on the Levels of Hydroxyl Radicals in a Non-Enzyme System |
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| Tang Lei,Hu Zhuoyi Division of Biochemistry.Effect of Calmodulin Antagonists on the Levels of Hydroxyl Radicals in a Non-Enzyme System[J].Journal of China Pharmaceutical University,1993(6). |
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| Authors: | Tang Lei Hu Zhuoyi Division of Biochemistry |
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| Abstract: | This article deals with the effect of Calmodulin antagonists (CaM A) on the levels of hydroxyl radicals ('OH) in a non-enzyme system. According to the result, Berbamine (E_0) and its derivatives (E_5, E_6), Dauricine (D_1) and Chlorpromazine (CPZ) can decrease 'OH level when at high concentration. All compounds tested can stimulate the formation of 'OH when at low concentration except for E_0 and CPZ. We draw a conclusion that using CaM A as a tool is practicable when studying the relationship of calmodulin and hydroxyl radicals. |
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| Keywords: | Calmodulin antagonist Non-enzyme system Hydroxyl radicals Phenothiazine derivatives Dauricine derivatives Berbamine derivatives |
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