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| 乙型肝炎病毒宫内传播的分子生物学证据 | |
| 引用本文： | 沈明洪,李笠,童舒平,闻玉梅. 乙型肝炎病毒宫内传播的分子生物学证据[J]. 山东大学学报(医学版), 1988, 0(4) |
| 作者姓名： | 沈明洪 李笠 童舒平 闻玉梅 |
| 作者单位： | 山东医科大学流行病学教研室(沈明洪，李笠)，上海医科大学(童舒平)，上海医科大学(闻玉梅) |
| 摘 要： | 采用病毒DNA分子杂交,Southern吸印及PAP等技术,从引产死婴心血及肝组织中发现HBV-DNA及HBsAg,从而为乙型肝炎病毒宫内传播提供了分子生物学证据。本研究还表明HBV宫内传播频率较低,为HBV母婴传播的产后立即特异性免疫预防提供了实践依据。 |
| 关 键 词： | 乙型肝炎病毒 乙型肝炎表面抗原 分子生物学 宫内传播 |
THE EVIDENCES IN MOLECULAR BIOLOGY FOR TRANSMISSION OF HBV FROM MOTHERS TO FETUSES IN UTERI |
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| Shen Minghong et al Dept.of Epidemiology,Shandong Medical University. THE EVIDENCES IN MOLECULAR BIOLOGY FOR TRANSMISSION OF HBV FROM MOTHERS TO FETUSES IN UTERI[J]. Journal of Shandong University:Health Sciences, 1988, 0(4) | |
| Authors: | Shen Minghong et al Dept.of Epidemiology Shandong Medical University |
| Abstract: | Forty eight heart blood samples and 48 liver tissues offetuses from induced abortions with HBsAg-positive mothers were collectedin Shanghai and Shandong.We detected HBV-DNA in 1 heart blood sa-mple and 2 liver tissues by spot hybridisation and southern blot.We alsofound HBsAg in 3 heart blood samples by radioimmunoassay and in 1liver tissue by PAP(peroxidase-anti-peroxidase).These results offerevidences in molecular biology for maternal-fetal transmission of HBV.Meantime the results suggest that the transmission in uteri is rare.There-fore hepatitis B vaccine and HBIG should be given immediately after birthto neonates born to HBsAg-positive mothers in order to prevent thetransmission. |
| Keywords: | Hepatitis B virus Hepatitis B surface antigens Molecular biology Transmission in uteri |
| 本文献已被 CNKI 等数据库收录！ | |