原子荧光光谱法同时测定药用玻璃容器中砷和锑的溶出量

目的:建立药用玻璃容器中砷、锑溶出量的测定方法。方法:采用断续流动进样方式,氢化物发生-原子荧光光谱法同时测定药用玻璃容器中砷、锑的溶出量。结果:砷在浓度范围为0～10.0μg.L-1内呈良好线性,r=0.999 9,检出限为0.009 0μg.L-1,平均回收率为95.08%;锑在浓度范围为0～10.0μg.L-1内呈良好线性,r=0.999 6,检出限为0.023 5μg.L-1,平均回收率为92.89%。结论:本法简便快捷,灵敏度高,专属性强,准确可靠,可作为药用玻璃容器的质量控制方法。

Extract of Arsenic and Antimony in Pharmaceutical Glass Containers Determinated by Atomic Fluorescence Spectrometry Simultaneously

Objective： To establish a method to determine the extract of arsenic and antimony in pharmaceutical glass containers. Methods ： By intermittent flow sampling methods, hydride generation-atomic fluorescence spectrometry, determine the extract of arsenic and antimony in pharmaceutical glass containers simultaneously. Results： In ＇the concentration range of 0 μg·L^-1- 10. 0 μg·L^-1arsenic showed a good linear relationship （r =0. 999 9）, the detection limit was 0. 009 0μg·L^-1 , the average recovery was 95.08% . In the concentration range of 0 μg·L^-1- 10. 0μg·L^-1 antimony showed a good linear relationship （r =0. 999 6）, the detection limit was 0. 023 5μg·L^-1, the average recovery was 92. 89%. Conclusion：This method is proved to be simple, sensitive, specific and reliable It can be used for the quality control of pharmaceutical glass containers.