| 鼻咽癌放疗后患者的放射性脑病与智能精神状态研究 |
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| 引用本文： | 周礼,陈赛,郑娟,何文. 鼻咽癌放疗后患者的放射性脑病与智能精神状态研究[J]. 中国医药导报, 2011, 8(14): 38-40 |
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| 作者姓名： | 周礼 陈赛 郑娟 何文 |
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| 作者单位： | 中山大学附属第一医院特诊中心,广东广州,510080 |
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| 摘 要： | 目的：分析广东地区鼻咽癌放疗后放射性脑病（radiation encephalopathy，RE）的临床和影像学特点，并对放射性脑病患者智能精神状态及其影响因素进行研究。方法：分析121例RE患者的临床资料，采用简易智能精神状态检查量表（MMSE）对63例RE患者（病例组）和66例疗程匹配的鼻咽癌放疗后无放射性脑病患者（对照组）进行评定。系统分析放射性脑病患者智能精神状态的变化、影响因素及与神经系统症状的相关性。结果：二程放疗后6个月内RE的发生率较一程放疗者差异有统计学意义（P〈O．05）；首发症状以球麻痹症状（65例，53．7l％）最常见。对照组MMSE评分为（25．38±1．98）分，病例组MMSE评分为（23．03±2．69）分，对照组智能精神状态的评分高于病例组（P〈0．05）；一程放疗组MMSE评分为（23．55±2．26）分，二程放疗MMSE评分为（21．29±3．41）分，两组评分比较。差异有统计学意义（P〈0．05）。球麻痹症状与智能精神状态的评分呈负相关。结论：二程放疗后RE发病率在2年内明显增加。RE对患者智能精神状态存在一定的负性影响，其中球麻痹等症状对智能精神状态的负面作用将会被考虑进来。
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| 关 键 词： | 鼻咽癌 放射性脑病 智能精神状态 |
Clinical analysis and study on the intelligent mental state of patients with radiation encephalopathy after radiotherapy of nasopharyngeal |
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| ZHOU Li,CHEN Sai,ZHENG Juan,HE Wen. Clinical analysis and study on the intelligent mental state of patients with radiation encephalopathy after radiotherapy of nasopharyngeal[J]. China Medical Herald, 2011, 8(14): 38-40 |
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| Authors: | ZHOU Li CHEN Sai ZHENG Juan HE Wen |
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| Affiliation: | ZHOU Li,CHEN Sai,ZHENG Juan,HE Wen Department of Special Clinic Center,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510008,China |
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| Abstract: | Objective:To investigate clinical manifestations and image features(MRI) of radiation encephalopathy(RE) in nasopharyngeal cancer(NPC) patients of Guangdong Province after radiotherapy and study on the intelligent mental state of the patients as well as influencing factors in RE.Methods:The clinical data of 121 patients of RE were retrospectively reviewed.The intelligent mental state was evaluated using the simple intelligent mental state inspection scale/ MMSE scale in 63 RE and 66 NPC patients received ra... |
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| Keywords: | Nasopharyngeal career Radiation encephalopathy Intelligent mental state |
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