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NS398 reduces hypoxia-inducible factor (HIF)-1alpha and HIF-1 activity: multiple-level effects involving cyclooxygenase-2 dependent and independent mechanisms
Authors:Zhong Hua  Willard Margaret  Simons Jonathan
Affiliation:Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA. hua_zhong@emoryhealthcare.org
Abstract:
Keywords:cell hypoxia, hypoxia‐inducible factor‐1α  nonsteroidal anti‐inflammatory drugs  cyclooxygenase‐2  prostaglandin E2  vascular endothelial growth factor  angiogenesis  protein ubiquitination
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