化痰方、肝脾方抗大鼠脂肪肝模型作用机制的比较研究

目的 :探讨和比较化痰方、肝脾方抗大鼠脂肪肝模型作用机制。方法 :用高脂饮食联合四环素腹腔注射致大鼠脂肪肝模型 ,观察肝组织病理变化 ,检测肝功能 (ALT、AST)、血甘油三酯 (TG)、肝匀浆TG、游离脂肪酸 (FFA)、丙二醛 (MDA)的含量。并与正常组、东宝肝泰组对照。结果 :三个用药组的血清ALT、AST及肝匀浆FFA、TG、MDA均显著低于模型组 (P <0 .0 1 ) ,并显示抗脂肪肝的作用强弱依次为 :肝脾组优于化痰组优于东宝组 (P <0 .0 5或P <0 .0 1 )。结论 :促进脂质代谢、抗脂质过氧化可能是化痰祛浊、疏肝健脾法治疗脂肪肝作用的主要机制

Comparative Study of the Efficacy of Huatanfang and Ganpifang on Fatty Liver in Rat Models

Objective:To explore and compare the mechanisms of actions of Huatanfang (HTF) and Ganpifang (GPF). Method: Models with fatty liver were made by giving rats high fat diet in combination with intraperitoneal injection of tetracycline to observe pathological changes of liver tissues, and detect the contents of ALT, AST, blood triglycerides ,hepatic TG, FFA, and MDA, which were compared with those of the normal group, and the group treated with Dongbao Gantai (DBGT).Result: The various indexes tested in the groups treated were markedly lower than those in the model group ( P <0.01). Results in the GPF group are better than those in the HTF group and DBGT group ( P <0.05 or P <0.01). Conclusion: To improve lipid metabolism and antagonize lipid peroxidation might be the mechanism of removing phlegm and dispersing liver and reinforcing spleen in treating fatty liver.