黄花乌头中生物碱类化学成分的研究

目的进一步研究毛茛科植物黄花乌头Aconitum coreanum的化学成分，寻找更多有活性的生物碱类物质。方法采用乙醇提取、溶剂萃取、氧化铝柱色谱方法进行分离纯化有关成分，根据理化性质和谱学分析(IR，ESI—MS，^1H—NMR，^13C—NMR，^1H-^1HCOSY，HMQC，HMBC)进行结构鉴定。结果从黄花乌头根中分离得到7个化合物，分别鉴定为：11，13-二乙酰基-14-羟基-2-异丁酰基-赫替新(11，13-diacetyl-14-hydroxy-2-isobutyryl hetisine，Ⅰ)、关附庚素(guan—fubase G，Ⅱ)、关附己素(guan—fu base F，Ⅲ)、关附Z素(guan—fu base Z，Ⅳ)、关附壬素(guan—fu base I，Ⅴ)、关附子素(guan—fu baseK，Ⅵ)、关附胺醇(guan—fu aminealcohol，Ⅶ)。结论化合物Ⅰ为新天然产物，命名为关附巳素(guan—fu base P)，首次报道其氢谱和碳谱数据。

Alka loid con stituen ts from root of Acon itum coreanum

search for more bioactive alkaloids from Acontum coreanurn through this fur-ther study.Methods The ethanolic extract from the root of A.coreanum was isola ted by a lum inium ox-idecolumn chromatography,the con stituent structures were eluc idated mainly by the iphysicochem icalprop-erties and spectroscop ic(IR,ES I-M S,1H-NM R,13C-NM R,1H-1HCO SY,HM QC,and HM -BC) analysis.