| XRCC1基因在肿瘤研究中的应用 |
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| 引用本文： | 傅锦业,吴毅. XRCC1基因在肿瘤研究中的应用[J]. 中国癌症杂志, 2007, 17(1): 92-94 |
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| 作者姓名： | 傅锦业 吴毅 |
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| 作者单位： | 复旦大学肿瘤医院头颈外科,复旦大学上海医学院肿瘤学系,上海,200032 |
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| 摘 要： | 肿瘤是一种基因病，基因组的稳定与否和肿瘤的发生密切相关。XRCC1基因是一种DNA损伤修复基因，在基因组损伤后的修复过程中发挥作用，对维持基因组的稳定，预防肿瘤的发生有着重要的意义。本文就XRCC1基因的生物学特点，该基因单核苷酸多态性与肿瘤易感性，以及该基因的研究方法等方面进行了文献回顾，为该基因用于肿瘤的预防、诊治提供理论借鉴。
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| 关 键 词： | XRCC1基因 肿瘤 |
| 文章编号： | 1007-3639（2007）01-0092-03 |
| 收稿时间： | 2006-09-12 |
| 修稿时间： | 2006-11-09 |
Application of XRCC1 gene in cancer research |
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| FU Jin-ye,WU Yi. Application of XRCC1 gene in cancer research[J]. China Oncology, 2007, 17(1): 92-94 |
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| Authors: | FU Jin-ye WU Yi |
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| Abstract: | Cancer is one of the gene diseases. The genome stability is closely associated with the occurrence of cancers. XRCC1 gene is one of the DNA repair genes. It participates in the repair process when the genome is injured. So it is considered important in maintaining the stability of the genome and in the prevention of tumor occurrence. This article introduced the characteristic of XRCC1 gene, the relationship between single nucleotide polymorphism of the gene and susceptibility to tumor, and the common methods used in the XRCC1 research. |
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| Keywords: | XRCC1 gene neoplasm |
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