饮用酒和乙醇对大鼠胃粘液分泌的影响

观察了饮用酒和乙醇对大鼠胃粘液分泌的影响。结果表明：饮用酒和乙醇胃内灌注显著增加胃粘液分泌，同剂量饮用酒作用比乙醇强，同时血浆促胃液素水平无显著改变；双侧膈下迷走神经切除或腹腔交感神经节及肠系膜上交感神经节切除都不影响此作用；十二指肠内灌注饮用酒仍有此作用；饮用酒和乙醇静脉注射不影响胃粘液分泌。提示：饮用酒和乙醇胃内灌注可增加胃粘液分泌，此作用与血浆促胃液素水平、迷走神经、交感神经以及饮用酒或乙醇的吸收无关。

Effects of spirituous liquor and ethanol on the secretion of gastric mucus in rats

The effect of spirituous liquor(54% ethanol, V/V) and ethanol(54%, V/V) on the secretion of gastric mucus was studied in rats, Spirituous liquor or ethanol administrated intragastrically(10 ml/kg) increased the quantity of barrier mucus(P<0. 001), but the level of serum gastrin did not change, There was no significant difference in the quantity of barrier mucus between normal rats and those which were vagotomized or sympathectomized. Spirituous liquor perfused intraduodenally(6ml/kg) increased the quantity of barrier mucus significantly(P<0.05). Both of them(4ml/kg)did not affect the quantity of barrier mucus intravenously. The results indicated that spirituous liquor or ethanol, as an irritant of the gastrointestinal tract, could stimulate gastric mucosa cells to increase the secretion of gastric mucus. This effect is not due to the absorption of ethanol, and has no relation with the vagus, the sympathetic nerve or the level of serum gastrin.