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| 瘦素、脂肪酸对大鼠胰岛细胞解偶联蛋白2 mRNA表达的影响 | |
| 引用本文： | 强桂芬,冯凭,崔景秋,郑宝忠,赵洪林,李颖利. 瘦素、脂肪酸对大鼠胰岛细胞解偶联蛋白2 mRNA表达的影响[J]. 中华内分泌代谢杂志, 2004, 20(4): 367-368 |
| 作者姓名： | 强桂芬 冯凭 崔景秋 郑宝忠 赵洪林 李颖利 |
| 作者单位： | 300052,天津医科大学总医院内分泌科 |
| 基金项目： | 天津市自然科学基金资助项目(023616811) |
| 摘 要： | 以瘦素、脂肪酸作用于体外培养的大鼠胰岛细胞，以甘油三酯含量，解偶联蛋白2 mRNA表达水平为指标，显示瘦素通过外周途径调节产热，脂肪酸可损害胰岛功能。 |
| 关 键 词： | 瘦素 mRNA表达 胰岛细胞 大鼠 解偶联蛋白2 脂肪酸 外周 产热 体外培养 水平 |
| 修稿时间： | 2003-02-25 |
Effect of leptin and fatty acids on uncoupling protein-2 mRNA in rat islet cells |
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| QIANG Gui-fen,FENG Ping,CUI Jing-qiu,ZHENG Bao-zhong,ZHAO Hong-lin,LI Ying-li. Effect of leptin and fatty acids on uncoupling protein-2 mRNA in rat islet cells[J]. Chinese Journal of Endocrinology and Metabolism, 2004, 20(4): 367-368 | |
| Authors: | QIANG Gui-fen FENG Ping CUI Jing-qiu ZHENG Bao-zhong ZHAO Hong-lin LI Ying-li |
| Affiliation: | QIANG Gui-fen,FENG Ping,CUI Jing-qiu,ZHENG Bao-zhong,ZHAO Hong-lin,LI Ying-li. Department of Endocrinology,The General Hospital of Tianjin Medical University,Tianjin 300052 |
| Abstract: | After rat pancreatic islets were isolated and cultured with leptin and fatty acids, intracellular triglyceride content and uncoupling protein-2 mRNA expression were measured. The results show that leptin can regulate thermogenesis by peripheral path-way and fatty acids may impair the function of islets. |
| Keywords: | Leptin Fatty acids nonesterified Triglycerides Uncoupling protein-2 Islets of Langerhans |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |