高强度聚焦超声致培养肿瘤细胞的温升效应

目的：探讨高强度聚焦超声对肿瘤细胞的影响。方法：观察人体卵巢上皮癌细胞受不同强度和时间的超声辐照后，肿瘤细胞的急性死亡率及肿瘤细胞的形态变化，增殖曲线和倍增时间。结果：不同的生物学效应与HIFU的声功率，照射时间呈正相关，一定强度的声功率下，照射时间愈长，其生物学效应越明显。结论：高强度聚焦超声能灭活肿瘤细胞且能撕裂肿瘤细胞。

Temperature Rising Effectof High Intensity Focused Ultrasound

Objective:To explore the effect of high intensity focusedultrasound(HIFU)on tumor cells.Methods：The mortality and morphologic changes of human ovarian epithilial carcinoma cells were observed after HIFU with different intensity and sonication duration.Results:There was positive correlation between biological effect and power of HIFU,focused domain and sonication duration.Under a definite power,the more time sonication spent,the more obvious biological effect existed.Conclusions:High intensity focused ultrasound can inactivate and dilacerate tumor cells.