流行性出血热灭活疫苗人群免疫及流行病学效果观察

为了观察EHF灭活疫苗的免疫力和流行病学效果,选择一个发病率在380～860/10万的集体单位职工作为疫苗接种组,并以该单位所在地的同一景观生活的农民作为对照组(发病率在170～120/10万之间)。1989年10月首次免疫接种后,抗EHF病毒NT抗体阳转率为148/150,HI抗体为149/150;2种抗体的几何平均滴度分别为80.67和38.68。1年后抗体阴转为20～25%。1990年9月加强免疫接种后,NT抗体阳转率为100%,几何平均滴度为81.85,1年后阴转率为5～8%。经3年的流行病学效果观察,观察点再未发生EHF病例,认为该疫苗足以控制本病流行。

Evaluation of the Efficacy and Epidemiology of the Inactivated EHF Vaccine-induced Antibodies

To observe the efficacy and the epidemiology of inactive HFRS vaccine in large population, a group of 150 people who live collectively in an epidemic area(yearly incidence of 380-860/100,000)were chosen to receive the innoculation, with another group of villigers living around the collective unit treated as control (annual incidences 120-170), of the 150 recipients, 148 show positive neutralizing responeses and 149 of them developed Hemagglutination inhibition specific Abs in their sera, with the average antibody titers of 80.6 and 38.68 respectively. Although Abs in 30 eases dissappeared one year later when booster injection was given, all 150 persons show a complete positive seroconversion, a higher mean titer(81.85), and much lower negative seroconversion rate (5-8%)after two injections. There have been no new patient of EHF diagnosed in this group since its first immunization in 1989-1991.