盐酸法舒地尔对冠心病心力衰竭患者心室重构和心功能的影响

目的：探讨盐酸法舒地尔对冠心病心力衰竭患者心室重构及心功能的影响。方法：冠心病心力衰竭患者80例,左室射血分数≤40%,心功能Ⅱ-Ⅳ级,常规治疗基础上随机分为治疗组和对照组,治疗3个月,观察法舒地尔对心室重构、心功能的影响。结果：经过3个月治疗,与对照组相比,法舒地尔组左室射血分数明显升高（P〈0.01）,左室收缩末容量指数、左室舒张末容量指数、左室重量指数均显著降低（P〈0.01）。结论：在常规治疗基础上,应用法舒地尔能显著改善冠心病心力衰竭患者的心功能,改善心室重构。

Effects of Fasudil Hydrochloride Therapy on The Left Ventricular Remodeling and Cardial Function in Patients with Coronary Heart Disease with Cardiac Dysfuction

Objective：To investigate the effect of Fasudil Hydrochloride on Cardiac funtion and ventricular remodeling in patients with coronary heart diease（CHD） and cardiac dysfunction.Methods： In 80 CHD patients with cardiac dysfuntion,the cardial function was grade Ⅱ～Ⅳ.On a basic of routine therapy,they were divided randomly into observational group and control group for afollow-up period of 3-month.The ventricular function and left remodeling were measured by echocardiography.Results： The left ventricular ejection fraction was increased significantly（P〈0.01）,and the left ventricular end-systolic volume index,the left ventricular end-diastdic volume index and the left ventricular mass index were decreased in observational group camppared with those in control group after 3 months（P〈0.05 and P〈0.01 respectively）.Conclusions：The routine treatment plus fasudil hydrochloride therapy can improve left Ventrcular functions and ventricular remodeling in CHD patient with heart failure.