Diastereomeric quinolinone alkaloids from the marine-derived fungus Penicillium janczewskii |
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| Authors: | He Jian Lion Ulrich Sattler Isabel Gollmick Friedrich A Grabley Susanne Cai Jingmin Meiners Marinus Schünke Henning Schaumann Karsten Dechert Ute Krohn Michael |
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| Affiliation: | Leibniz-Institute for Natural Products Research and Infection Biology, Hans-Kn?ll-Institute, Beutenbergstrasse 11a, D-07745 Jena, Germany. |
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| Abstract: | From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells. |
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