Predicting carotid restenosis by comparison of plaque MCP-1 mRNA expression and serum levels |
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| Authors: | Ines Strenja Linic Ivan Sosa Miljenko Kovacevic Aldo Ivancic Zlatko Trobonjaca Darko Ledic Aron Grubesic Stefica Dvornik Sanja Stifter |
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| Affiliation: | 1. Cerebrovascular Clinic, Department of Neurology, Clinical Hospital Centre Rijeka, Croatia;2. Department of Forensic Medicine and Criminalistics, Rijeka University Medical School, Croatia;3. Thoracovascular Surgery Clinic, Department of Surgery, Clinical Hospital Centre Rijeka and Rijeka University Medical School, Croatia;4. Department of Physiology and Immunology, Rijeka University Medical School, Croatia;5. Neurosurgery Clinic, Department of Surgery, Rijeka Clinical Hospital Centre Rijeka and Rijeka University Medical School, Croatia;6. Institute for Emergency Medicine, Rijeka, Croatia;g Clinical Department of Laboratory Diagnostic, Rijeka Clinical Hospital Centre Rijeka and Rijeka University Medical School, Croatia;h Department of Pathology, Rijeka University School of Medicine, Croatia |
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| Abstract: | As cardiovascular pathology grows in numbers, research into the discovery of new chemokine biomarkers should not be neglected, as they seem to be paramount in atherosclerosis prevention and its early detection. Chemokines attract and activate leukocytes and are well recognized in the environment of inflammatory response. MCP-1 is a valuable chemokine whose potential to become a new crucial atherosclerosis marker is surely worth investigating. Since quantities of MCP-1 found in lesions are as low as immeasurable, we propose the use of an immunohistochemical method for the quantification of MCP-1 levels in atherosclerotic lesions. Additionally, serum levels of MCP-1 can be measured by commercially available immunoassays. Proposed MCP-1 concentration increase may explain the acceleration in lesion’s atherosclerosis progression as chemokine activation occurs once they bind to specific ligands. If proven, this hypothesis would indicate the need for further studies in order to objectively link the increased MCP-1 expression with carotid restenosis. |
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