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| 硬膜外吗啡与氯胺酮用于术后镇痛的临床观察 | |
| 引用本文： | 陈东生,陈国忠. 硬膜外吗啡与氯胺酮用于术后镇痛的临床观察[J]. 临床军医杂志, 2008, 36(5) |
| 作者姓名： | 陈东生 陈国忠 |
| 作者单位： | 解放军南京军区福州总医院,麻醉科,福建,福州,350025;解放军南京军区福州总医院,麻醉科,福建,福州,350025 |
| 摘 要： | 目的研究吗啡联合氯胺酮单次注入硬膜外术后镇痛效果和不良反应。方法选择下肢骨折手术患者66例,随机分成两组,全部选择硬膜外麻醉。局麻药使用利多卡因、丁卡因混合液。吗啡组(M组)药物配方为吗啡2 mg,氯胺酮联合吗啡组(KM组)药物配方为吗啡2 mg+氯胺酮10 mg。均以生理盐水稀释到5 ml。手术结束前半小时将各组药物注入硬膜外腔,观察注药前、后10 min SBP、DBP、HR、SpO2的变化,48h内镇痛效果及不良反应。结果两组药物对循环呼吸功能均无明显改变。KM组的疼痛评分在各时间点均明显低于M组在相同时间点的疼痛评分(P<0.01),而不良反应M组和KM组之间差异无统计学意义(P>0.05)。结论硬膜外吗啡联用氯胺酮术后镇痛有镇痛效果确切、持续时间长、术后镇静满意、患者感觉良好的优点,是一种更为切实可行的方法。 |
| 关 键 词： | 硬膜外 术后镇痛 吗啡 氯胺酮 |
Clinical Study of Postoperative Epidural Analgesia with Morphine and Ketamine |
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| Chen Dong-sheng,Chen Gou-zhong. Clinical Study of Postoperative Epidural Analgesia with Morphine and Ketamine[J]. Clinical Journal of Medical Officer, 2008, 36(5) | |
| Authors: | Chen Dong-sheng Chen Gou-zhong |
| Affiliation: | Chen Dong-sheng,Chen Gou-zhong(Department of Anesthesiology,Fuzhou General Hospital of Nanjing Military Region,PLA,Fuzhou 350025,China) |
| Abstract: | Objective To study the analgesic efficacy and disadvantageous influence of postoperative analgesia with epidural injection of morphine and ketamine.Methods Sixty-six patients undergoing surgical operation in lower limbs were randomly divided into two groups(n=33/group).Epidural anesthesia was performed with mix drug of lidocanine hydrochloride and dicaine hydrochloride.Postoperative analgesia was performed with 2 mg of morphine(Group M) or 2 mg of morphine and 10 mg of ketamine(Group KM).Half hour before th... |
| Keywords: | epidural postoperative analgesia morphine ketamine |
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