阿托伐他汀对急性百草枯中毒鼠肺p38MAPK表达及肺损伤的影响

目的 探讨阿托伐他汀对大鼠百草枯(PQ)中毒急性肺损伤(ALI)的保护作用及其机制.方法 选择健康SD大鼠60只,随机分为3组:PQ组、阿托伐他汀组和对照组.PQ组和阿托伐他汀组腹腔内注射PQ,阿托伐他汀组给予阿托伐他汀1.5 mg/(kg·d)灌胃治疗;对照组注射等体积无菌生理盐水.7 d后测支气管肺组织p38丝裂原...

Protective effect of atorvastatin on paraquat-induced injury in rat pulmonary microvascular endothelial cells expression of p38MAPK in rats

Objective To study the protective effect of atorvastatin on paraquat-induced injury in rats and the mechanism.Methods Sixty rats were enrolled and randomly divided into three groups:contrast group,paraquat group and atorvastatin group.Peritoneal paraquat injection were performed in paraquat group and atorvastatin group,while equal volume of saline was peritonealy injected in contrast group,atorvastatin group injected with paraquat 12 h,given atorvastatin 1.5 mg/(kg·d)by the injection tube.Seven days later,the expression of p38MAPK,the nurmber of NF-κB positive cells,inflammatory cells in bronchoalveolar lavage fluid(BALF)and the levels of IL-6 and TNF-α in the serum were measured.Results The expression of p38MAPK,the nurmber of NF-κB positive cells,the total number of cells,neutrophilic granulocytes,macrophage in BALF and the levels of IL-6 and TNF-α in the serum were significantly increased in paraquat group and atorvastatin group(P<0.05).But their levels in atorvastatin group were lower than that in paraquat group(P<0.05).Conclusion In paraquat-induced acute lung injury rat models,atorvastatin can alleviate inflammatory response and lung injury,inhibit the expression of p38MAPK and activity of NF-κB,possess potential protective effects.