先天性心脏病并肺动脉高压患儿血清一氧化氮和血浆内皮素变化的意义

目的　探讨血清一氧化氮 (NO)和血浆内皮素 1(ET 1)对先天性心脏病 (CHD)患儿肺动脉高压 (PH)形成的影响。方法　选择健康儿童 3 0例为对照组 (A组 ) ;3 0例肺动脉压正常的CHD患儿为B组 ;3 0例CHD并PH患儿为C组。采用硝酸还原法对其血清NO 2 /NO 3 、放免法对其血浆ET 1浓度进行测定。结果　B组血清NO 2 /NO 3 浓度较A组明显增高 ;C组血清NO 2 /NO 3 浓度较A组低 ;无论是否并PH ,A、B两组与对照组相比 ,其血浆ET 1浓度均增高。结论　血清NO 2 /NO 3 浓度和血浆ET 1浓度及其间平衡关系共同影响PH的形成及其程度

Observation of serum nitric oxide and plasma endothelin in children with congenital heart disease complicated pulmonary hypertension

Objective To explore the effects of serum nitrous ox ide(NO) and plasma endothelin(ET-1) on pulmonary hypertension in congenital he art disease (CHD)children.Methods Thirty healthy children were randomly selected as control group(A group), another 30 children with CHD and normal pulmonary arterial pressure(PAP) as B group, and the other 30 children w ith CHD and pulmonary hypertension(PH) were in the experimental group as C gr oup.The concentrations of serum NO and plasma ET-1 in each group were measure d with nitric acid-restored method and radioactive-immunization method. Results Serum NO 2/NO 3 in B group was higher than that of A group. Serum NO 2/NO 3 in C group was lower than that of A group. Plasm a ET-1, with or without PH, children's plasma ET-1 was higher than that of A group.Conclusion The concentration of serum NO 2/NO 3 a nd plasma ET-1 and the balance relationship between them may affect the format ion and the extent of PH.