健脾醒胃消滞方配合莫沙必利治疗2型糖尿病胃轻瘫所致便秘脾胃虚弱证的疗效及对自主神经功能的影响

目的 探讨健脾醒胃消滞方配合莫沙必利治疗2型糖尿病胃轻瘫所致便秘脾胃虚弱证患者的疗效及对自主神经功能的影响.方法 将2018年3月—2019年8月在南宁市红十字会医院治疗的98例2型糖尿病胃轻瘫所致便秘脾胃虚弱证患者随机分为2组,对照组49例采用2型糖尿病基础治疗+莫沙必利治疗,研究组49例在对照组治疗基础上采用健脾醒...

Efficacy of Jianpi Xingwei Xiaozhi Decoction combined with mosapride on constipation due to type 2 diabetic gastroparesis of type of spleen-stomach deficiency and its influence on autonomic nerve function

Objective It is to explore the curative effect of Jianpi Xingwei Xiaozhi Decoction combined with mosapride on constipation due to type 2 diabetic gastroparesis of type of spleen-stomach deficiency and its influence on autonomic nerve function.Methods Ninety-eight patients with constipation caused by type 2 diabetic gastroparesis of type of spleen-stomach deficiency,treated in Nanning Red Cross Hospital from March 2018 to August 2019 were randomly divided into 2 groups,49 patients in the control group were treated with basic therapy for type 2 diabetes+mosapride,49 cases in the study group were treated with Jianpi Xingwei Xiaozhi Decoction on the basis of the control group,both groups were treated for 4 weeks.The clinical efficacy,constipation symptom scores,gastric emptying rate,gastric electrogram indexes[proportional dominant amplitude(PDP),proportional dominant frequency(PDF)],heart rate variability indexes(SDANN,RMSSD,SDNN,LF,HF,LF/HF),the scores of life quality and the occurrence of adverse reactions were compared in the two groups.Results The total effective rates in the study group and the control group were 95.6%(45/49)and 73.7%(36/49),respectively,the study group was significantly higher than the control group(P<0.05).After treatment,the scores of constipation symptoms,satisfaction,physical discomfort,worry and anxiety,and psychosocial discomfort in the two groups were significantly reduced(P<0.05),while the gastric emptying rate,PDP,PDF,SDANN,RMSSD,SDNN,LF,HF and LF/HF were significantly increased(P<0.05),and the improvement of the above indicators in the study group was significantly better than that in the control group(P<0.05).The incidence of adverse reactions in the study group and the control group were 6.1%(3/49)and 4.1%(2/49)respectively,and the difference was not significant(P>0.05).Conclusion Jianpi Xingwei Xiaozhi Decoction combined with mosapride can significantly improve the clinical efficacy,significantly improve autonomic nerve function and the quality of life without increasing adverse reactions in the treatment of constipation due to type 2 diabetic gastroparesis of type of spleen-stomach deficiency.