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Loss of interstitial cells of Cajal network in severe idiopathic gastroparesis |
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| Authors: | Battaglia Edda Bassotti Gabrio Bellone Graziella Dughera Luca Serra Anna-Maria Chiusa Luigi Repici Alessandro Mioli Pierroberto Emanuelli Giorgio |
| Affiliation: | 1. Department of Gastroenterology and Clinical Nutrition, University of Torino,Italy 2. Gastroenterology Section, Department of Clinical and Experimental Medicine, University of Perugia, Italy 3. Department of Biomedical Sciences and Human Oncology, University of Torino, Italy 4. Department of Emergency Surgical Unit, San Giovanni Battista Hospital, Torino, Italy |
| Abstract: | AIM: To report a case of severe idiopathic gastroparesis in complete absence of Kit-positive gastric interstitial cells of Cajal (ICC). METHODS: Gastric tissue from a patient with severe idiopathic gastroparesis unresponsive to medical treatment and requiring surgery was analyzed by conventional histology and immunohistochemistry. RESULTS: Gastric pacemaker cells expressing Kit receptor had completely disappeared while the local level of stem cell factor, the essential ligand for its development and maintenance, was increased. No signs of cell death were observed in the pacemaker region. CONCLUSION: These results are consistent with the hypothesis that a lack of Kit expression may lead to impaired functioning of ICC. Total gastrectomy proves to be curative. |
| Keywords: | C-kit Gastroparesis Interstitial cells of Cajal Stem cell factor |
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